肝脏脂肪浸润程度与胰岛素抵抗的相关性研究

The relationship between degree of fat accumulation in the liver and insulin resistance

目的 探讨非酒精性脂肪肝 (NFL)肝脏脂肪浸润程度与胰岛素抵抗的关系。方法检测NFL组 2 6例和正常对照组 18例的血脂、血糖、胰岛素、游离脂肪酸 (FFA ) ,采用稳态模式评价胰岛素抵抗 (HOMA IR)。根据肝脏脂肪含量 (LFC)中位数 ( 4 .3 4% ) ,将NFL组分为低含量组(LLFC)和高含量组 (HLFC)。结果 LLFC组和HLFC组空腹胰岛素、2小时胰岛素和HOMA IR水平高于正常对照组 (P <0 .0 5 )。校正了年龄和血糖影响后 ,LFC仍与FINS和HOMA IR呈正相关。多元逐步回归显示 ,腰臀比、BMI是影响NFL肝脏脂肪含量独立的危险因素。结论 NFL患者肝脏脂肪浸润程度与胰岛素抵抗密切相关 ,腰臀比。

Objective To investigate relationship between degree of liver fat accumulation in patients of nonalcoholic fatty liver(NFL) and insulin resistance.Methods Serum lipids,glucose,insulin,free fatty acid(FFA) were measured in 26 patients of NFL and 18 control subjects(C).Homeostasis model assessment(HOMA) was applied to assess the status of insulin resistance.The patients of NFL were divided into low liver fat content(LLFC) and high liver fat content(HLFC) groups according to median of liver fat content(LFC)(4.34%).Results The result showed that FINS,2hINS and HOMA-IR were significantly elevated in the subjects of LLFC and HLFC compared with C(P<0.05).Partial correlation analysis showed that LFC was positively correlated to FINS and HOMA-IR,after adjusted age and glucose.Multiple stepwise regression analysis showed that WHR and BMI were the independent risk factors affected LFC.Conclusion The result suggested that insulin resistance was positively related to LFC in subjects of NFL.WHR and BMI were the independent risk factors affected LFC.