同轴电纺制备豆腐果苷芯鞘结构纳米纤维固体分散体研究

Research on Solid Dispersion of Helicid-loaded Core/Sheath Hanofibers Prepared Using Coaxial Electro spinning

制备并表征了水难溶药物的芯鞘结构纳米纤维型固体分散体。以聚乙烯吡咯烷酮为成纤基材,以豆腐果苷为难溶药物模型,采用同轴高压静电纺丝工艺制备出芯鞘载药纳米纤维。扫描电镜结果表明芯鞘纳米纤维具有空间立体三维连续网状结构,纤维粗细均匀;透射电镜观察表明纳米纤维具有清晰的芯鞘结构特征;X-射线晶体衍射结果表明豆腐果苷以无定形态高度分散于纳米纤维中;芯鞘载药纳米纤维明显提高了豆腐果苷的溶解度。同轴电纺能够为改善难溶药物的溶出特征提供有效的措施。

The study investigated a solid dispersion of poorly water-soluble drug in the form of core/sheath nanofibers.Using Polyvinylpyrrolidone as the filament-forming matrix and helicid as the drug model,coaxial electro spinning was exploited to prepare the core/sheath nanofibers.Scanning electron microscopy demonstrated that the nanofibers had a continuous three-diemnsional web structure with an average diameter of 740 ± 90 nm.Transmission electron microscopy observations showed that the nanofibers had a clear core/sheath nanostructure.X-ray diffraction analyses verified that the drug helicid presented in the core-sheath nanofibers was essentially in an amorphous state.In vitro dissolution tests showed that the core/sheath nanofibers could significantly improve the drug dissolution rate,exhausting within 60 s.Coaxial electro spinning can be a useful tool for providing resolutions for enhancing dissolution properties of poorly-water soluble drugs.