消癌解毒方联合FEC化疗对乳腺癌患者临床疗效的影响

Clinical Efficacy of Xiaoai Jiedu Formula Combined with FEC Chemotherapy on Breast Cancer Patients

目的:观察消癌解毒方联合氟尿嘧啶+表柔比星+环磷酰胺(5-FU+EPI+CTX,FEC)化疗方案对乳腺癌患者的免疫功能、肿瘤指标、中医证候积分、不良反应发生情况的影响。方法:将60例乳腺癌患者随机分为研究组和对照组,研究组进行FEC(CTX 0. 6 g·m^(-2),d1,EPI 100 mg·m^(-2),d1,5-FU 0. 5 g·m^(-2),d1)方案化疗,同时服用消癌解毒方制剂,连续服用2个周期,对照组单纯进行FEC方案化疗。2个周期后分析并比较两组的免疫功能、肿瘤指标、中医证候评分、不良反应发生情况的差异。结果:治疗前两组免疫指标相当,治疗后研究组免疫指标优于对照组(P <0. 05);治疗前两组患者癌胚抗原(CEA)和糖类抗原153(CA153)水平比较差异无统计学意义,与本组治疗前比较,治疗后两组CEA,CA153水平均明显下降,且研究组下降幅度更为明显(P <0. 05);两组治疗前胸胁不适、潮热盗汗、急躁易怒、口干口苦、睡眠积分比较差异无统计学意义,与本组治疗前比较,治疗后研究组中医证候积分低于对照组(P <0. 05);研究组患者不良反应发生率均低于对照组(P <0. 05)。结论:消癌解毒方联合FEC化疗能提高患者的免疫能力和临床疗效,改善患者的临床症状。

Objective: To observe effect of Xiaoai Jiedu formula combined with fluorouracil( 5-FU) +epirubicin( EPI) + cyclophosphamide( CTX)( FEC) chemotherapy regimen on immune function,tumor index,traditional Chinese medicine( TCM) symptom scale score and adverse reactions of patients with breast cancer.Method: A total of 60 patients with breast cancer were randomly divided into study group and control group. FEC( CTX 0. 6 g·m-2,d1,EPI 100 mg·m-2,d1,5-FU 0. 5 g·m-2,d1) regimen was used in study group,and Xiaoai Jiedu formula recipe was used for two consecutive cycles. FEC regimen was used in control group only. After2 cycles,immunological changes,tumor index,TCM symptom score and adverse reactions were analyzed and compared between two groups. Result: There was not significant difference in immune indexes between two groups before treatment,but statistically significant differences after treatment( P < 0. 05). There was no statistically significant difference in levels of carcinoembryonic antigen( CEA) and carbohydrate antigen153( CA153)between two groups before treatment;CEA and CA153 levels significantly decreased in both groups,particularly in study group( P < 0. 05). There was no statistically significant difference in scores of fatigue,hot flashes and night sweats,irritability,dry mouth,appetite and sleep between two groups before treatment. The scores in study group were significantly lower than those in control group after treatment( P < 0. 05). The incidence of menstrual disorder,nausea,vomiting and constipation in study group was lower than that in control group( P < 0. 05).Conclusion: Xiaoai Jiedu formula combined with FEC chemotherapy can improve clinical efficacy and alleviate clinical symptoms of patients.