基于量表学与组学建立中医证候宏微观辨证体系的可行性探讨

Discussion on Feasibility of Establishing Macro-micro Syndrome Differentiation System of Traditional Chinese Medicine Based on Scale and Omics

证候是中医学辨证论治的依据与精髓,其综合概括了机体在内外因素作用下的整体性反应状态,具有主观、定性的特点。而现代医学用以诊断疾病的检验指标具有客观、定量的特征。将主观、定性的中医证候进行量化处理,与客观、定量的现代检验指标相结合,为中医证候辨证体系的现代化发展提供了的新思路。该文以高血压前期肝阳上亢证为例,运用量表学与代谢组学数据建立证候判别模型,就中医证候宏微观辨证体系的构建进行可行性探讨,对实现中医证候诊断的客观化以及辨证论治的规范化、标准化具有重要的指导意义。

Syndrome is the basis and essence of the treatment according to syndrome differentiation theory in traditional Chinese medicine(TCM),which comprehensively summarizes the overall reaction state of the organism under the influence of internal and external factors,and has subjective and qualitative characteristics.But the test indexes of modern medicine for diagnosing diseases have the objective and quantitative characteristics.The subjective and qualitative TCM syndromes can be quantitatively treated and combined with the objective and quantitative modern test indexes,this method provides a new idea for the modernization of syndrome differentiation system of TCM.In this paper,the prehypertension with syndrome of upper hyperactivity of liver Yang was taken as an example,a syndrome discriminant model was set up by using the technique of scale and metabonomics,and the feasibility of establishing macro-micro syndrome differentiation system of TCM was also discussed.This paper has important guiding significance for realizing the objectification of diagnosis of TCM syndrome and the standardization of the treatment according to syndrome differentiation theory of TCM.