二陈汤研究进展

Research Progress of Erchentang

二陈汤出自成书于北宋的《太平惠民和剂局方》,是历代公认的祛痰剂祖方,该方组方严谨,配伍精当,即可理气,又能化痰,对痰饮证及相关疾病的疗效确切。近些年来,围绕此方的作用机制研究不断扩展与深化。根据收集的资料显示,近年来关于二陈汤的研究多与治疗呼吸系统疾病相关,即便是其他系统的疾病也往往通过中医理论'从肺论治',为疾病的治疗提供了新的思路。二陈汤的研究多数为二陈汤的加味或者合方,基于此,通过对研究资料的收集,发现呈现此特点的原因与历代医家的用药规律有关。药理学的研究成为当下的热门,常涉及多个信号传导通路,来探讨二陈汤的多靶点治疗作用。药理学研究也以对呼吸系统疾病的治疗作用为主,特别是慢性阻塞性肺疾病(COPD),研究内容尤为详尽。将从二陈汤的文献研究,临床研究,药理学研究等方面为二陈汤的研究进展做简要的概述。最新的文献研究对理解二陈汤的内涵大有裨益,而多位研究者通过最新的检测技术阐明了二陈汤在机体内的作用机制。

Erchentang originated from Taiping Huimin Heji Ju Fang written in the Northern Song Dynasty,is recognized as the ancestor prescription of expectorant in past dynasties.The prescription is rigorous and well-matched,which can regulate Qi and expectorate phlegm.It has a definite curative effect on phlegm-drinking syndrome and related diseases.In recent years,the research on the mechanism of action has expanded and deepened.According to the collected data,in recent years,the research on Erchentang is mostly related to the treatment of respiratory diseases.Even other diseases of the system are often treated from the lung through the theory of traditional Chinese medicine,which provides a new way of thinking for the treatment of diseases.Most of the studies on Erchentang are flavored or combined prescriptions of Erchentang.Based on this,through the collection of research data,it is found that the reasons for this characteristic are related to the medication rules of doctors in past dynasties.Pharmacological research has become a hot topic,often involving multiple signal transduction pathways,to explore the multi-target therapeutic effect of Erchentang.Pharmacological research is also focused on the treatment of respiratory diseases,especially chronic obstructive pulmonary disease(COPD),the research content is particularly detailed.This paper will briefly summarize the research progress of Erchentang from the aspects of literature research,clinical research and pharmacological research.The latest literature research is helpful to understand the meaning of Erchentang,and many researchers have clarified the mechanism of Erchentang in vivo through the latest detection technology.