难治性强迫症胶质细胞源性神经营养因子水平与认知功能被引量：11

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摘要目的探讨难治性强迫症(obsessive-compulsive disorder,OCD)患者血清中胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)的浓度水平与认知功能之间的关系。方法纳入41例难治性强迫症患者和57名性别、年龄、受教育年限相匹配的正常对照作为研究对象,采用酶联免疫法测定血清中GDNF的浓度水平,采用Yale-Brown强迫量表(Yale-Brown obsessive-compulsive scale,Y-BOCS)评估患者强迫症状,用成套神经心理状态评估工具(repeatable battery for the assessment of neuropsychological status,RBANS)对患者组和对照组的认知功能进行评定。结果患者组血清GDNF水平低于对照组[(7.11±1.65)pg/m L vs.(9.16±2.14)pg/m L],差异有统计学意义(P<0.01);认知功能方面,患者组语言功能比对照组差[(89.12±12.13)vs.(98.52±9.37)],差异具有统计学意义(P<0.01)。难治性强迫症患者血清GDNF水平与性别、起病年龄、病程、Y-BOCS总分及RBANS总分无统计学相关性(P>0.05)。结论难治性强迫症患者语言功能存在障碍,GDNF与强迫症的发生可能具有相关性。

作者陈茜胡嘉波周朝昀肖文焕沙维伟

机构地区江苏省检验医学重点实验室江苏扬州五台山医院

出处《中国神经精神疾病杂志》 CAS CSCD 北大核心 2015年第8期497-500,共4页 Chinese Journal of Nervous and Mental Diseases

基金扬州市2012科技攻关-社会发展科技攻关项目(编号:yzSGG-201230024)

关键词难治性强迫症胶质细胞源性神经营养因子认知功能临床研究

分类号 R749 [医药卫生—神经病学与精神病学]

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