吸烟对总胆固醇及踝臂指数的影响

Effect of smoking on total cholesterol and ankle brachial index

目的探讨吸烟对总胆固醇及踝臂指数(ABI)的影响,为健康教育和临床干预提供资料。方法 147例住院和门诊受试者,分为吸烟组(84例)及非吸烟组(63例),并明确吸烟指数,比较两组年龄、总胆固醇、ABI及ABI减低、总胆固醇增高发生情况;分析吸烟组ABI与吸烟指数相关性。结果吸烟组ABI(0.911±0.078)低于非吸烟组的(0.945±0.076),差异具有统计学意义(P<0.05);吸烟组ABI减低发生率为56.0%,低于非吸烟组的31.7%,差异具有统计学意义(P<0.05)。两组年龄、总胆固醇、总胆固醇增高发生率比较差异无统计学意义(P>0.05)。经直线相关性分析,吸烟组ABI与吸烟指数呈负相关(r=-0.329, P<0.05)。结论吸烟患者ABI减低, ABI与吸烟指数呈负相关,吸烟对总胆固醇代谢无明显影响,吸烟合并总胆固醇增高者, ABI明显减低。故吸烟及总胆固醇增高可以加快动脉粥样硬化硬化的发展。

Objective To discuss the effect of smoking on total cholesterol and ankle brachial index(ABI), and provide data for health education and clinical intervention. Methods A total of 147 inpatients and outpatients were divided into smoking group(84 cases) and non-smoking group(63 cases). The smoking index, age, total cholesterol, ABI and ABI decrease and total cholesterol increase were compared between the two groups. The correlation between ABI and smoking index in smoking group was analyzed. Results Smoking group had lower ABI as(0.911±0.078) than(0.945±0.076) in non-smoking group, and the difference was statistically significant(P<0.05). Smoking group had lower incidence of ABI decrease as 56.0% than 31.7% in non-smoking group, and the difference was statistically significant(P<0.05). Both groups had no statistically significant difference in age, total cholesterol and incidence of total cholesterol increase(P>0.05). Linear correlation analysis showed that there was a negative correlation between ABI and smoking index in smoking group(r=-0.329, P<0.05). Conclusion ABI decrease and ABI was negatively correlated with smoking index. Smoking has no significant effect on total cholesterol metabolism. ABI was significantly reduced in smoking patients with total cholesterol. Therefore, smoking and increased total cholesterol can accelerate the development of atherosclerosis.