精神分裂症患者肝胆超声筛查结果分析

Analysis of results of hepatobiliary ultrasound screening in patients with schizophrenia

目的探讨服用抗精神病药物的精神分裂症患者肝胆超声影像改变。方法选取服药治疗>3年的精神分裂症患者330例作为研究组,另选取同期未服药健康体检者120例作为对照组,两组均采用肝胆超声影像学检查。比较两组研究对象的肝胆超声检查结果。结果研究组患者中肝胆超声检查异常131例,异常率39.7%;对照组肝胆超声检查异常27例,异常率22.5%。研究组肝胆超声检查异常率明显高于对照组,差异具有统计学意义(χ~2=11.423, P=0.0007<0.05)。肝胆超声检查异常主要集中在脂肪肝、胆囊结石、胆囊息肉、胆管结石。其中单纯脂肪肝比例均为最高,研究组为91例(27.6%),对照组为15例(12.5%),研究组的单纯脂肪肝率明显高于对照组,差异有统计学意义(χ~2=11.107,P=0.001<0.05);脂肪肝总例数:研究组为110例(33.3%),对照组为19例(15.8%),研究组脂肪肝率明显高于对照组,差异有统计学意义(χ~2=13.179, P=0.0003<0.05)。两组的肝胆系统疾病如胆囊结石、胆囊息肉、胆管结石的发生率比较,差异均无统计学意义(P>0.05)。结论精神分裂症患者长期服用抗精神病药物会对其肝胆功能产生损害,超声可以作为首选的检查方法 ,建议服药期间定期进行肝胆超声检查,以便早期发现、早期治疗。

Objective To discuss the changes of hepatobiliary ultrasound images in patients with schizophrenia taking antipsychotics.Methods A total of 330 schizophrenia patients taking medicine>3 years were selected as research group,and concurrent 120 healthy people without taking medicine as the control group.Both groups were examined by hepatobiliary ultrasonography.The results of hepatobiliary ultrasonography in two groups were compared.Results The research group had 131 cases of abnormal hepatobiliary ultrasonography,accounting for 39.7%,while the control group had 27 cases of abnormal hepatobiliary ultrasonography,accounting for 22.5%.The research group had obviously higher abnormal rate of hepatobiliary ultrasonography than the control group,and the difference was statistically significant(χ~2=11.423,P=0.0007<0.05).The abnormalities of hepatobiliary ultrasonography mainly concentrated in fatty liver,gallstone,gallbladder polyp,bile duct stone.Among them,the proportion of simple fatty liver was the highest,with 91 cases(27.6%)in research group and15 cases(12.5%)in the control group.The research group had obviously higher simple fatty liver ratio than the control group,and the difference was statistically significant(χ~2=11.107,P=0.001<0.05).The research group had 110 fatty liver cases(33.3%),which was 19 cases(15.8%)in the control group.The research group had obviously higher fatty liver rate than the control group,and the difference was statistically significant(χ~2=13.179,P=0.0003<0.05).Both groups had no statistically significant difference in incidence of hepatobiliary diseases such as gallstones,gallbladder polyps,and bile duct stones(P>0.05).Conclusion Schizophrenia patients taking antipsychotic drugs for a long time will damage their hepatobiliary function.Ultrasound can be the preferred method of examination.It is suggested that regular hepatobiliary ultrasound should be carried out during medication for early detection and treatment.