脂质代谢、体质量指数与乳腺癌发生的关系

Correlation of lipid metabolism, body mass index and breast cancer

目的探讨血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体质量指数(BMI)与乳腺癌发生的关系。方法选取确诊为乳腺癌的患者293例作为实验组,另选取无乳腺疾病的健康人群170例作为对照组。比较两组研究对象的临床资料[年龄、TC、HDL-C、LDL-C、空腹血糖(Glu)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血肌酐(CREA)、肾小球滤过率(GFR)、BMI、地区(城镇、乡村)、绝经状态(绝经前、后)]及两组绝经前后临床资料(年龄、TC、HDL-C、LDL-C、Glu、ALT、AST、CREA、GFR、BMI)。结果两组的年龄、LDL-C、Glu、ALT、AST、CREA、GFR、地区、绝经状态比较,差异均无统计学意义(P>0.05)。实验组的BMI为(23.50±3.172)kg/m^2,显著高于对照组的(22.68±2.04)kg/m^2,差异有统计学意义(P<0.05);实验组的TC为(4.78±0.93)mmol/L、HDL-C为(1.02±0.29)mmol/L,均低于对照组的(5.04±0.90)、(1.15±0.38)mmol/L,差异均具有统计学意义(P<0.05)。绝经前,实验组的BMI(23.66±3.21)kg/m^2明显高于对照组的(22.55±2.01)kg/m^2,差异具有统计学意义(P<0.05);实验组的TC、HDL-C水平分别为(4.62±0.94)、(1.01±0.29)mmol/L,均低于对照组的(4.93±0.87)、(1.25±0.36)mmol/L,差异均具有统计学意义(P<0.05);两组的年龄、LDL-C、Glu、ALT、AST、CREA、GFR水平比较,差异均无统计学意义(P>0.05)。绝经后,两组的年龄、TC、HDL-C、LDL-C、Glu、ALT、AST、CREA、GFR、BMI水平比较,差异均无统计学意义(P>0.05)。结论乳腺癌患者的BMI显著升高, TC、HDL-C水平显著降低,但绝经后患者的各项指标变动不大,因此,临床绝经前患者可通过检测BMI、TC、HDL-C水平为诊断其是否患有乳腺癌提供相关数据支持。

Objective To discuss the correlation of serum total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),body mass index(BMI)and occurrence of breast cancer.Methods A total of 293 patients diagnosed with breast cancer were selected as the experimental group,and 170 healthy people without breast disease were selected as the control group.Analysis and comparison were made on clinical data[age,TC,HDL-C,LDL-C,fasting blood glucose(Glu),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum creatinine(CREA),glomerular filtration rate(GFR),BMI,regions(town,country),menopausal status(before or after menopause),and clinical data(age,TC,HDL-C,LDL-C,Glu,ALT,AST,CREA,GFR,BMI)before or after menopause between the two groups.Results There was no statistically significant difference in LDL-C,Glu,ALT,AST,CREA,GFR,region,menopausal status between the two groups(P>0.05).The BMI was(23.50±3.17)kg/m^2 in the experimental group,and that was significantly higher than(22.68±2.04)kg/m^2 in the control group,and the difference was statistically significant(P<0.05).The TC and HDL-C were(4.78±0.93)and(1.02±0.29)mmol/L in the experimental group,and those were lower than(5.04±0.90)and(1.15±0.38)mmol/L in the control group.Their difference was statistically significant(P<0.05).Before menopause,the BMI was(23.66±3.21)kg/m^2 in the experimental group,and that was obviously higher than(22.55±2.00)kg/m^2 in the control group,and the difference was statistically significant(P<0.05).The levels of TC and HDL-C were(4.62±0.94)and(1.01±0.29)mmol/L respectively in the experimental group,and those were all lower than(4.93±0.87)and(1.25±0.36)mmol/L in the control group.Their difference was statistically significant(P<0.05).There was no statistically significant difference in age,LDL-C,Glu,ALT,AST,CREA and GFR between the two groups(P>0.05).After menopause,there was no statistically significant difference in age,TC,HDL-C,LDL-C,Glu,ALT,AST,CREA,GFR,BMI between the two groups(P>0.05).Conclusion The BMI of breast cancer patients is significantly increased,and the levels of TC and HDL-C are significantly decreased,but the indicators of patients after menopause are not changed much.Therefore,BMI,TC and HDL-C levels can be detected to provide relevant data support for the diagnosis of breast cancer in patients before menopause.