液基细胞学联合p16、Ki67用于诊断宫颈上皮内瘤变的意义

Significance of liquid-based cytology combined with p16 and Ki67 in the diagnosis of cervical intraepithelial neoplasia

目的探究液基细胞学联合p16、Ki67用于诊断宫颈上皮内瘤变(CIN)的意义。方法 225例CIN患者为研究对象,分别给予液基细胞学、p16、Ki67检测,比较液基细胞学、p16、Ki67单独检测及联合检测的诊断准确率。结果液基细胞学联合Ki67、p16检测的诊断准确率为100.00%,显著高于液基细胞学、p16、Ki67单独检测的91.56%、88.44%、86.67%,差异均具有统计学意义(χ~2=19.838、27.594、32.143, P=0.000、0.000、0.000<0.05)。液基细胞学、p16、Ki67单独检测的诊断准确率两两比较,差异均无统计学意义(P>0.05)。结论将液基细胞学联合p16、Ki67应用于CIN诊断中,可显著提升诊断准确度,值得应用与推广。

Objective To investigate the significance of liquid-based cytology combined with p16 and Ki67 in the diagnosis of cervical intraepithelial neoplasia(CIN).Methods A total of 225 CIN patients as study subjects,and all were tested by liquid-based cytology,p16 and Ki67,respectively.The diagnostic accuracy of single and combined detection of liquid-based cytology,p16 and Ki67 were compared.Results The diagnostic accuracy of combined detection of liquid-based cytology,p16 and Ki67 was 100.00%,which was significantly higher than 91.56%,88.44%and 86.67%of single detection of liquid-based cytology,p16 and Ki67,and the difference was statistically significant(χ~2=19.838,27.594,32.143,P=0.000,0.000,0.000<0.05).There was no significant difference in diagnostic accuracy among liquid-based cytology,p16 and Ki67(P>0.05).Conclusion Combined detection of liquid-based cytology,p16 and Ki67 in CIN diagnosis can significantly improve the diagnostic accuracy,and it is worthy of application and promotion.