血栓弹力图与常规凝血试验的相关性研究

Study on the correlation between thromboelastogram and routine coagulation test

目的研究血栓弹力图(TEG)与常规凝血试验的相关性。方法 126例需进行输血治疗的住院重症患者,均行常规凝血四项检查和TEG检查,分析患者TEG与常规凝血试验指标的相关性与一致性。结果反应时间(R值)与血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均呈显著的正相关关系(r=0.227、0.248, P<0.05),与血浆纤维蛋白原(FIB)、血小板(Plt)均无相关性(P>0.05);凝固时间(K值)、Angle角(Α-Angle)、最大振幅(MA值)与FIB、Plt均呈显著的正相关关系(r=0.456、0.537、0.655,0.426、0.531、0.630, P<0.05),与PT、APTT均无相关性(P>0.05)。R值与PT、APTT均无一致性(κ=0.037、0.058, P>0.05), K值、Α-Angle、MA值与FIB、Plt均存在一致性(κ=0.321、0.286、0.425, 0.377、0.206、0.350, P<0.05)。结论 TEG与常规凝血试验存在一定的相关性,但具有较弱的一致性,无法相互取代。

Objective To study the correlation between thromboelastogram(TEG)and routine coagulation test.Methods A total of 126 hospitalized severe patients requiring blood transfusion treatment all received four items of routine coagulation and TEG test.The correlation and consistency between TEG and routine coagulation test indicators were analyzed.Results The reaction time(R value)was positively correlated with plasma prothrombin time(PT)and activated partial thromboplastin time(APTT)(r=0.227,0.248,P<0.05),but not with plasma fibrinogen(FIB)and platelet(Plt)(P>0.05).The coagulation time(K),Angle angle(A-Angle)and maximum amplitude(MA)were positively correlated with FIB and Plt(r=0.456,0.537,0.655;0.426,0.531,0.630,P<0.05),but not with PT and APTT(P>0.05).The R value was not consistent with PT and APTT(κ=0.037,0.058,P>0.05).The K value,Angle,MA value were consistent with FIB and Plt(κ=0.321,0.286,0.425;0.377,0.206,0.350,P<0.05).Conclusion TEG has certain correlation with routine coagulation test,but it has weak consistency and can not be replaced by each other.