可降解血管支架结构设计及优化的研究进展

Research Progress on the Structure Design and Optimization of Biodegradable Stents

可降解血管支架具有完全可吸收性和良好的生物相容性,可避免永久性支架易导致血管再狭窄、药物洗脱支架面临迟发性支架内血栓等的问题,引领介入治疗领域的'第四代'革新。然而,可降解支架服役过程中表现出支撑力不够、降解过快等力学性能不足的问题,使其距临床应用还有一段距离。针对这个问题,支架的结构设计及优化是提高支架支撑性能、延长可降解支架服役时间的有效方法。支架的结构设计及优化也是一个复杂过程,涉及力学性能之间的相互平衡、血流动力学以及腐蚀过程中支架支撑性能变化等问题。综述可降解支架结构设计及优化的国内外研究现状,并在此基础上阐述可降解支架结构设计及优化研究面临的挑战,展望可降解支架结构设计及优化研究的发展方向。

Due to the advantages of degradability and excellent biocompatibility,the biodegradable alloy stents,are expected to be the promising solution for the problems such as the restenosis of the permanent stents,the late stents thrombosis of drug eluting stents,leading the fourth generation of innovation in the field of the cardiovascular interventional therapy.However,insufficient scaffold performance and too short degradation time are the main limitations for the biodegradable stents in clinical application currently.To deal with these problems,stent design and optimization can be an effective method to improve scaffold performance of biodegradable stents and prolong their service time.Structure design and optimization of biodegradable stents is a complex process involving balance of different mechanical performances,hemodynamics and the changing of scaffold performance in corrosion environment.Therefore,in this article,the state-of-the-art design and optimization of the biodegradable stents were reviewed and the challenges and future research directions were pointed out.