Noninvasive Brain Neuromodulation Based on Low-Intensity Focused Ultrasound Stimulation

Low-intensity focused ultrasound stimulation(FUS), which possesses high spatial resolution and penetration depth, has been developing rapidly for noninvasive brain neuromodulation in recent years. In this letter, a low-intensity FUS system was developed for noninvasive brain neuromodulation in vivo. The radius of ultrasonic focal spot was quantitatively calculated in theory to evaluate the spatial resolution. The local field potential(LFP) of rat hippocompus were recorded before and after FUS. The effect of FUS on LFP power spectrum was investigated by computing the LFP mean absolute power and relative power with Welch algorithm. The experiment results show that noninvasive FUS can enhance LFP mean absolute power and alter the LFP relative power at different frequency bands. The results indicate that FUS can modulate brain rhythms and has significant potential in the modulation of neuronal and psychiatric diseases.