血清地高辛放射免疫分析在心血管疾病中的初步应用

A Preliminary Application of Serum Digoxin Radioimmunoassay in Cardiovascular Diseases

地高辛(Digoxin)属于毛地黄类药物,是治疗心力衰竭和心律紊乱的有效强心药,由于该药物的治疗剂量与中毒剂量较接近,病人对药物的敏感性不同,尤其在应用药量不清,吸收不良或肾功能不好的情况下,如何正确测出血中地高辛浓度,用以指导临床医生用药,是临床急需解决的问题。但由于地高辛在血中的浓度很低(毫微克量级)一般方法很难测准。

A study of serum digoxin RIA kit in 32 Cases is here reported. Ten normal subjects (male 4, female 6, aged 25-45) whose mean serum digoxin concentration was 0.06±0.07ng/ml did not receive digoxin, and 22 patients with cardiovascu-lar disease (male 13, female 9, aged 14-69) whose mean serum digoxin concentration was 1.98±1.12 ag/ml, received digoxin maintenance doses (0.125-0.25 mg/day).Three out of 22 Patients were clinically digoxin intoxicated(13.6%)and had concentrations of serum digoxin 2.43±0.76ng/ml. In the other 19 nonintoxicated patients, the mean was 1.91 ±1.16ng/ml. The results of the determination was statistically analysed and discussed. Serum digoxin radioimmunoassay is helpful in evaluating intoxication in digoxin therapy.