鼻咽癌与ABO、MN血型和分泌型的关系

Association of Nasopharyngeal Carcinoma ( N PC ) with ABO, MN Blood Groups and Secretor Group

血型是典型的孟德尔式遗传性状,研究鼻咽癌与血型的关系无疑是寻找本病遗传标记的途径之一。 鼻咽癌与血型关系的研究,国外报道较多,国内报道较少。为了与国内外的研究结果比较,我们分析了广东人的鼻咽癌与血型的关系。 限据广东省恶性肿瘤死亡调查结果和新加坡的报道,发现在广东省内不同方言地区,鼻咽癌的发病率有较大的差异,这一现象提示不同方言人群可能存在着遗传异质性。为了排除这种可能存在的异质性对分析结果的影响。

This paper reports a Comparative analysis between ABO, MN blood groups of 1137 Kwantung patients diagnosed as NPC pathologically and that of 979 non- NPC persons.Results of comparative analysis of secre-tor group of 442 NPC patients and that of 435 non-cancer persons are also included.X2 tests and cutting total x2 tests showed that there was no statistical significant difference in ABO, MN phynotype frequencies and in secretor group between patients and control s. Anyhow, by means of t-tests, significant difference was seen in Se gene frequency ( P< 0.05) though it was not presented in A, B, 0, M and N gene frequen-cie s.In order to remove heterogeneity which may exist in the populations both patients and controls were divided into three dialect subgroups, Cantonese, Hakka and Teochew. Bofh x2 tests and cutting total X2 tests showed there is no significant difference of phynotype frequ encies between patients and controls within each one of the 3 dialect subgroups and also no statistical difference between patients in these subgroups.