摘要
二氨基嘧啶类抗菌增效剂是一类广谱、高效的药物,广泛应用于临床。综述二氨基嘧啶类抗菌增效剂的毒性作用,主要包括急性毒性、长期毒性、遗传毒性等,以期为评价其安全性,指导临床合理使用,开发新药,避免应用危害提供参考。
Diaminopyrimidine antibacterial synergist is a kind of high-efficiency,low-toxic drug,widely used in clinical practice. This paper reviews the toxicity of diaminopyrimidine antimicrobial synergists,mainly including acute toxicity,long-term toxicity and genetic toxicity,in order to provide a reference for evaluating their safety,guiding clinical rational use,developing new drugs and avoiding the harm of their application.
作者
郭京超
孙亚奇
刘振利
王旭
袁宗辉
GUO Jing-chao;SUN Ya-qi;LIU Zhen-li;WANG Xu;YUAN Zong-hui(National Reference Laboratory of Veterinary Drug Residues(HZAU),Key Laboratory of the Detection for Veterinary Drug Residues,Ministry of Agriculture,P.R China,Huazhong Agricultural University,Laboratory of Quality&Safety Risk Assessment for Livestock and Poultry Products(Wuhan),Ministry of Agriculture,P.R China,Huazhong Agricultural University,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China)
出处
《中国兽药杂志》
2019年第1期77-84,共8页
Chinese Journal of Veterinary Drug
基金
国家重点研发计划(2017YFD0501405)
