黑龙江省佳木斯地区高尿酸血症与代谢性疾病的相关性分析

The analyze of relationship between hyperuricemia and metabolic diseases in Jiamusi area of Heilongjiang province

目的了解黑龙江省佳木斯地区高尿酸血症(HUA)的患病率并分析其与其他代谢性疾病的相关性。方法选取1249例佳木斯大学附属第一医院2017年8月-2018年6月健康体检者,分为高尿酸血症组(HUA组,n=316)与非高尿酸血症组(NUA组n=933),进行统计学分析。结果1.HUA患病率为25.3%,男性明显高于女性(35.10%VS 13.7%);2.HUA组中各代谢性疾病的患病率均显著高于NUA组(P<0.05);HUA组内男性与女性比较,HHcy及超重/肥胖的患病率男性较高,高血糖患病率女性较高,PHUA<0.05;3.BMI、TG、LDL-C与HUA呈正相关,GLU(OR=0.835,P<0.01)、HDL-C(OR=0.190,P<0.01)分别与男性、女性HUA呈负相关。结论HUA患病率较高,且伴发各个代谢性疾病罹患率亦较高,BMI、TG、LDL-C是HUA危险因素,GLU、HDL-C分别是男女HUA的保护性因素。

Objective To study the prevalence of hyperuricemia(HUA)in Jiamusi area of Heilongjiang province and to analyze its relativity with metabolic diseases.Methods 1249 healthy test people from the First Affiliated Hospital of Jiamusi University from August 2017 to June 2018 were divided into hyperuricemia group(HUA group,n=316)and non-hyperuricemia group(NUA group,n=933)and were analyzed statistically.Results 1.The prevalence rate of HUA was 25.3%,and the rate in male was distinctly higher than in female(35.10%vs 13.7%).2.Compared with NUA group,the prevalence rate of metabolic diseases in HUA group was higher(P<0.05).Compared with women in HUA group,the prevalence of HHCY and overweight/obesity was higher in men and higher in women with hyperglycemia,P<0.05.3.BMI,TG,LDL-C were positively correlated with HUA,Glu(OR=0.835,P<0.01)and HDL-C(OR=0.190,P<0.01)negatively correlated with HUA in men and women,respectively.Conclusion The prevalence rate of HUA is high,and the incidence of metabolic diseases in HUA is also high.BMI,TG,LDL-C are risk factors for HUA,while Glu and HDL-C are protective factors for HUA in men and women,respectively.