前列腺癌组织中p27、bcl-2蛋白的表达水平及临床意义

Clinical significance and expression of p27,bcl-2 proteins in prostatic carcinoma

目的探讨不同前列腺组织中p27、bcl-2蛋白的表达水平及临床意义。方法收集活检或手术切除前列腺组织标本,按病理诊断分为前列腺癌组30例、前列腺增生组20例;其中前列腺癌组又分为高分化组(13例)、中低分化组(17例)。应用免疫组织化学SP法检测上述标本中p27、bcl-2蛋白的表达。结果 p27蛋白在前列腺癌组织中的阳性表达率(23.3%)显著低于前列腺增生组织中的阳性表达率(85.0%),差异具有统计学意义(P<0.05);bcl-2蛋白在前列腺癌组织中的63.3%阳性率,显著高于前列腺增生组织中的10.0%阳性率,差异具有统计学意义(P<0.05);p27在前列腺癌高分化组的阳性表达率(46.1%)显著高于中低分化组(5.9%)(P<0.05),bcl-2蛋白在前列腺癌高分化组的阳性表达率(38.5%)显著低于中低分化组(82.4%)(P<0.05)。结论 p27、bcl-2蛋白的异常表达与前列腺癌的发生发展密切相关,检测p27和bcl-2蛋白水平在前列腺癌鉴别及临床预后具有一定的价值。

Objective To explore the expression of p27 and bcl-2 proteins in different prostate tissue and their clinical significances.Methods In this study,about 30 prostatic carcinoma patients and 20 benign prostatic hyperplasia patients were collected by biopsy and exairesls,while 30 prostatic carcinoma patients were divided to high differentiated group(n=13)and medium-poor entiated group(n=17).The expressions of p27 and bcl-2 protein were measured by SP immnohistochemical.Results The positive expression rates of p27 was 23.3%in prostatic carcinoma,which was significantly lower than those of benign prostatic hyperplasia(P<0.05).The positive expression rates of bcl-2 was63.3%in prostatic carcinoma,which was significantly higher than those of benign prostatic hyperplasia(P<0.05).The level of p27 in the group of well-differentiated was 46.1%,which was significantly higher than those in the medium-poor differentiated group(5.9%)(P<0.05).The bcl-2 positivelevel in well-differentiated prostatic carcinoma was38.5%,which was significantly lower than those in the medium-poor differentiated group(82.4%)(P<0.05).Conclusion The deregulationof p27 and bcl-2 protein may play important roles in tumori genesis and progression of prostatic carcinoma.Detections of p27 and bcl-2 protein are useful for clinical prognosis.