胃癌淋巴结微转移的意义

The significance of Llmph node micrometastasis in gastric cancer

目的 :研究胃癌淋巴结微转移的意义。方法 :用常规 HE和免疫组化 CK1 9检测 10 0例胃癌淋巴结转移。结果 :10 0例胃癌中 ,76例淋巴结明显转移 ,6例淋巴结微转移 ,18例无转移。在 P2 7Kip1 和 P5 3表达及 5年生存期上胃癌淋巴结微转移组与转移组比较差异均有显著性 (P<0 .0 5 ) ;相反 ,微转移组与无转移组比较差异均无显著性 (P>0 .0 5 )。结论 :胃癌淋巴结微转移对预后因子 P2 7Kip1 和 P5 3蛋白表达和 5年生存期影响不大 ,依据免疫组化检测胃癌淋巴结微转移灶方法敏感可行 ,但对胃癌患者的临床治疗与预后意义不大。

Objective:The study was designed to investigate the significance of micrometastasis in gastric carcinoma.Methods:The metastasis and micrometastasis in lymph node were determined by routine HE and immunohistochemistry assay.Results:Of the 100 patients, there were 76 patients with lymph node metastasis, 6 patients with micrometastasis and 18 patients with no lymph node metastasis. In the expression of P27 Kip1 protein?P53 protein and 5 year survival rate, the group of lymph node metastasis had statistic significance (P<0.05) to on group of lymph node micrometastasis. On the contrary, the group of lymph node micrometastasis had no statistic significance(P>0.05) on the group of lymph node without metastasis.Conclusions:The lymph node metastasis in gastric carcinoma had little influence to the expression of P27 Kip1 protein?P53 protein and 5 year survival rate. The method was sensitive to the assay of micrometastasis in lymph node of gastric carcinoma by immunohistochemistry, but there was little significance in therapy and prognosis.