Ki-67在垂体腺瘤中的表达及其意义

The protein expression of Ki-67 and its significance in pituitary adenomas

目的 :探讨垂体腺瘤中 Ki- 6 7蛋白表达与肿瘤增殖间的关系 ,进一步了解侵袭性垂体腺瘤的生物学特性 ,以提高诊断治疗水平。方法 :搜集 5 6例垂体瘤患者的临床综合资料 ,应用免疫组化 SP法 ,利用 MIB- 1检测 Ki- 6 7标记指数 ,了解肿瘤细胞的侵袭性和增殖能力。结果 :Ki- 6 7的表达在侵袭性腺瘤组明显高于非侵袭性腺瘤组。各种类型的垂体腺瘤 (PRL 腺瘤、GH腺瘤、ACTH腺瘤、非功能性腺瘤 )其侵袭的发生率无明显差异。侵袭性腺瘤组和非侵袭性腺瘤组在肿瘤大小、瘤内出血坏死、囊变发生率等方面有显著差异。结论 :侵袭性垂体腺瘤多为大腺瘤 ,肿瘤出血、坏死、囊变发生率高 ,肿瘤增殖能力强。Ki- 6 7标记指数可作为评价垂体腺瘤侵袭性的重要参考指标。

Objective:To study the relationship between the protein expression of Ki-67 and tumor proliferation and find out the biological characteristics of invasive pituitary adenomas. Methods:The protein expression of Ki-67 was examined by immunohistochemical SP methods in 56 pituitary adenomas.Results:The invasive group had a high expression of Ki-67 than that of noninvasive group. Significant clinical difference existed between two groups in size, the incidence of hemorrhage, necrosis and cystic components.Conclusion:Invasive pituitary adenoma was larger and had a high incidence of hemorrhage, necrosis and cystic components. The Ki-67 Labling Indices(LI) can be considered as an important indicator to evaluate the tumor invasive protential.