L-精氨酸对胎儿宫内发育迟缓患者母血及脐血一氧化氮水平的影响(英文)

Effect of L-arginine on nitric oxide levels of maternal and neonatal umbilical blood in intrauterine growth retardation

目的 有研究表明一氧化氮 (NO)减少可能在胎儿宫内发育迟缓 (IUGR)的发生发展中起重要作用 ,该文探讨L 精氨酸 (L Arg)对IUGR孕妇外周血及新生儿脐血中NO水平的影响。 方法 选择IUGR孕妇 6 6例 ,其中常规治疗组 36例 ,予以常规治疗 ;L Arg组 30例 ,在常规治疗的基础上加用L Arg治疗。选择正常初产妇30例作为正常对照组。监测治疗前后孕妇血清NO水平变化及脐静脉血清NO水平。结果 治疗后 ,L Arg组孕妇血清NO水平显著高于常规治疗组 (5 8.4 2± 2 3.1 2 μmol/Lvs4 3.4 9± 2 0 .2 7μmol/L) (P <0 .0 1 ) ;L Arg组胎儿脐静脉血清NO水平显著高于常规治疗组 (2 5 .2 3± 1 2 .0 5 μmol/Lvs1 6 .95± 1 1 .1 9μmol/L) (P <0 .0 1 )。结论 L

Objective It has been reported that nitric oxide (NO) might play an important role in the development of intrauterine growth retardation (IUGR). This paper aims at investigating the effect of L arginine (L Arg) on NO levels of maternal and neonatal umbilical blood in IUGR. Methods Sixty six pregnant women with IUGR were recruited. Thirty six cases were given routine therapy (Routine therapy group), and the other 30 cases were given L Arg combined with routine therapy (L Arg group). Another 30 cases with normal pregnancy were used as Normal control group. The NO levels of maternal and neonatal umbilical blood were monitored before and after treatment. Results After the treatment, the maternal serum NO level in the L Arg group was significantly higher than that of the Routine therapy group ( 58.42 ± 23.12 μmol/L vs 43.49 ± 20.27 μmol/L) (P< 0.01 ). The umbilical blood NO level in the L Arg group was alao significantly higher than that of the Routine therapy group ( 25.23 ± 12.05 μmol/L vs 16.95 ± 11.19 μmol/L) (P< 0.01 ). Conclusion L Arg can increase serum NO levels of both maternal and umbilical blood in IUGR.