摘要
农业害虫对杀虫剂抗性的持续增加,严重威胁着农业可持续发展和人类生存。高效、安全的新型农药的创制是有效控制害虫的重要保证。胆固醇是昆虫细胞膜和脂蛋白的重要组成成分,是类固醇激素的合成前体。但昆虫本身缺乏合成胆固醇的关键酶,无法从头合成胆固醇,需要从植物中摄取。甾醇载体蛋白2(SCP-2)在昆虫转运胆固醇的过程中起着关键作用。SCP-2可以作为筛选高效安全新农药的潜在靶标。本文就近几年筛选出的甾醇载体蛋白2抑制剂进行了总结。
The increasing resistance of agricultural pests to pesticides seriously threatens the sustainable development of agriculture and human survival. The research of new pesticides with high efficiency and safety ensures sustainable pest control. Cholesterol, an important component of insect cell membrane and lipoprotein, is a synthetic precursor of steroid hormones. However, insects can’t synthesize cholesterol from scratch because of lacking the key enzyme, and need to take cholesterol from plants. Sterol carrier protein-2(SCP-2) plays a key role in insect transport of cholesterol. SCP-2 can be used as a potential target for screening new pesticides with high efficiency and safety. This article summarized the sterol carrier protein-2 inhibitors screened out in recent years.
作者
陶涛
杜馨
TAO Tao;DU Xin(Hubei Collaborative Innovation Center for Industrial Fermentation,Key Laboratory of Fermentation Engineering,Ministry of Education,College of Biological Engineering and Food,Hubei University of Technology,Wuhan 430068,China)
出处
《植物保护》
CAS
CSCD
北大核心
2019年第2期30-36,共7页
Plant Protection
基金
国家自然科学基金(31401807)
湖北工业大学博士启动基金(BSQD13002)
湖北工业大学教学研究项目(2015051)
关键词
甾醇载体蛋白2
害虫防治
新农药创制
筛选方法
抑制剂
sterol carrier protein 2
pest control
development of new pesticide
screening method
inhibitor
