时辰化疗对肿瘤患者免疫功能的影响及护理

The Effects of Chrono-Chemotherapy on Immune Function for Patients with Malignant Tumor

目的:对比观察时辰化疗和常规化疗对恶性肿瘤患者免疫功能的影响。方法:将82例经病理学或细胞学确诊的初治恶性肿瘤患者随机分为两组,时辰化疗组(CC组):42例,常规化疗组(RC组):40例。结果:时辰化疗组:①CD_8^+、B细胞较化疗前上升,但差异无显著性。(P>0.001);②CD_3^+、CD_4^+/CD_8^+、CD_8^+CD_(28)^+较化疗前有显著上升,差异有显著性。(P<0.001);③CD_8^+、CD_8^+CD_(28)^-、NK细胞较化疗前显著下降,差异有显著性。(P<0.001).常规化疗组:①CD_3^+、CD_4^+较化疗前上升,但差异无显著性.②CD_8^+较化疗前略有上升,但差异无显著性。③CD_4^+/CD_8^+、CD_8^+CD_(28)^+、CD_8^+CD_(28)^-较化疗前略有下降,但差异无显著性.④NK细胞、B细胞较化疗前有下降,但差异无显著性。(P>0.001)。结论:时辰化疗是一种的合理、有效的化疗方法,与常规化疗相比,时辰化疗使患者近期的细胞免疫功能得到明显提高;良好的护理是保证时辰化疗顺利实施的关键。

Objective To compare the effects on immune function of the chrono—chemotherapy with the routine—chemotherapy for patients with malignant tumor.Methods Eighty—two patients with pathological-proved untreated malignant tumor were randomly divided into the chronological chemotherapy group(group CC,42 cases) and the routine chemotherapy group(group RC,40 cases).Results In the group CC,the CD3+ and B cell were no significant difference between pre—and post-chemotherapy(P>0.001),the CD4 +、CD4+/CD8 +、CD8 + CD28+ were significantly increased and CD8+、CD8+ CD28-、NK cell were significantly decreased in group CC(P<0.001).While the changes of the measures of immune function were not significant in the group RC(P>0.001).Conclusions The chrono—chemotherapy is a reasonable and effective way of chemotherapy,and compared with the routine chemotherapy, it can improve the short—term cellular immune function of malignant tumor patients.Good nursing is very importent to the chrono—chemotherapy.