摘要
目的:探讨引起新生儿血小板减少症的相关因素。方法:回顾苏州大学附属儿童医院新生儿科收治的73例新生儿血小板减少症的临床诊断、围产期因素、实验室检查等来分析新生儿血小板减少症的相关因素。结果:新生儿血小板减少症按发生时间分为:早发型和晚发型血小板减少症,其相关因素是复杂多样的,其中,妊高症、胎膜早破、免疫性疾病与早产儿血小板减少症的关联性显著,而羊水污染与足月儿血小板减少症的关联性显著;围产期窒息、低出生体重、肺炎、与早发型血小板减少症的关联性显著,各种院外感染、院内感染、低出生体重、适于胎龄儿与晚发型血小板减少症的关联性显著。结论:新生儿血小板减少症在新生儿科尤其NICU的临床上并不少见的,国外报道其发病率在活产新生儿中达1%-5%,而引起新生儿血小板减少症的相关因素是复杂多样的,对此进行分析以了解与新生儿血小板减少症的关联性。
Objective To study the relevant factors of thrombocytopenia in the neonates.Methods Retrospective method was applied to analyze 73 cases neonates with thrombocytopenia in department of neonatal paediatrics.Clinical diagnosis,perinatal causes,lab findings were observed.Results Neonatal thrombocytopenia contains the early—onset neonatal and late—onset neonatal thrombocytopenia in term of occurring time.Their relevant factors are complicated and various.Relevance of thrombocytopenia in preterm infants is remarkable with maternal pregnancy—induced hypertension,premature rupture of memberane and immune disease.But relevance of thrombocytopenia in term infants is notable with amniotic fluid pollution.Associativity of the early—onset neonatal thrombocytopenia is significant with perinatal asphyxia,low birth weight and pneumonia.And associativity of the late-onset neonatal thrombocytopenia is significant with various community infections,nosocomial infections,term infant and AGA.Conclusion Thrombocytopenia is not rare in the department of neonatal paediatrics,particularly in NICU.It was reported that the incidence of thrombocytopenia in live birth neonates reaches 1%-5%.However relevant factors of neonatal thrombocytopenia are complicated and various.Analysis of relevant factors is to understand the relevance associated with neonatal thrombocytopenia.
