米非司酮配伍利凡诺用于中孕引产的临床研究

The study of the combination of Lee rivanol and Mifepristone in inducing labor in middle stage of pregnancy

目的:探讨在中孕引产中米非司酮配伍利凡诺的临床效果。方法:将中孕引产患者200例随机分为观察组和对照组,分别采用米非司酮配伍羊膜腔注射利凡诺引产和单独采用羊膜腔注射利凡诺引产,对引产成功率及清宫率、胎儿胎盘娩出时间、总产程、产后出血量进行比较。结果:观察组完全成功率明显高于对照组,差异有统计学意义(P<0.05),不完全成功率即清宫率明显低于对照组,差异有统计学意义(P<0.05);观察组引产时间及总产程明显短于对照组,差异有统计学意义(P<0.05);观察组产后出血量少于对照组,但差异无统计学意义(P>0.05)。结论:对于中孕引产,米非司酮配伍羊膜腔注射利凡诺与单独羊膜腔注射利凡诺比较,明显缩短了引产时间,降低了清宫率,值得临床推广。

Objective To study the treatment effects of the combination of Lee rivanol and Mifepristone in inducing labor in middle stage of pregnancy. Methods 200 cases in midtrimester of pregnancy were divided into observation group and control group randomly.Rivanol combined with Mifepristone was used in the study group.The control group only used Lee rivanol.The success rate of inducing of labor and the rate of cleaning uterine cavity,the inducing time,total labor time and postpartum bleeding volume were compared between them.Results The success rate of inducing of labor of the study group was significantly higher than that in the control group and there was significant difference between them(P<0.05).The rate of cleaning uterine cavity of the study group was less than that of the control group and there were significant difference between them(P<0.05).The inducing time and total labor time in the study group were obviously shorter than that in the control group and there was significant difference between them(P<0.05).The postpartum bleeding volume of the study group was less than that in the control group,but there was no statistic difference between them(P>0.05).Conclusion The combination of Lee rivanol and Mifepristone which shorted the total labor time and the inducing time and reduced the rate of cleaning uterine cavity was worthy of clinical application.