摘要
目的:分析比较胸腺切除与药物治疗儿童型重症肌无力(MG)的临床疗效。方法:收集我院54例小儿重症肌无力患者的临床资料,随机分成胸腺切除组和药物治疗组,每组27例,比较分析不同性别、年龄、病程、临床分型对两种不同治疗方案临床疗效的影响。结果:1年内药物治疗组症状完全缓解8例(29.6%),症状改善7例(25.9%),总有效率为55.6%;胸腺切除组症状完全缓解11例(40.7%),症状改善8例(29.6%),总有效率为70.4%,两组间完全缓解率和总有效率差异无统计学意义(P>0.05)。两组治疗有效患者性别构成、年龄以及病程无统计学差异(P>0.05)。讨论:药物应为对因治疗的首选,对于药物难以控制病例可考虑采用胸腺切除手术治疗。
Objective To analyse and compare the clinical efficacy of thymectomy and drug therapy in children with myasthenia gravis(MG).Methods Cllected the clinical data of the 54 cases of myasthenia gravis in pediatric patients,which were randomly divided into the thymus resection group and treatment group,27 cases in each group,analyseed and compareed different gender,age,course of disease,clinical typing of two different treatment regimens in clinical curative effect.Result In drug treatment group within 1 years of complete remission of symptoms in 8 cases(29.6%),symptoms improved in 7 cases (25.9%),the total efficiency of 55.6%;In thymus resection group complete remission of symptoms in 11 cases(40.7%),symptoms improved in 8 cases(29.6%),the total efficiency of 70.4%,among two groups of complete remission rate and total effective rate between the difference was not statistically significant(P>0.05).Two groups of patients with effective treatment of sex,age and duration was no statistical difference(P>0.05).Conclusion The drug treatment should be first choice,for using drug are difficult to control case can be considered the treatment of thymus resection operation.
