健康成年男性血清睾酮水平对血脂代谢影响的初步研究

Influence of testosterone level on lipid metabolism in healthy adult males

目的初步探讨健康成年男性血清睾酮水平对血脂代谢等的影响。方法采用常规方法检测188例健康成年男性(素食者86例,杂食者102例)血脂等生化指标及睾酮水平,用气相色谱法测定血浆磷脂脂肪酸构成。结果睾酮与总蛋白、前白蛋白、总胆固醇、低密度脂蛋白胆固醇无显著性相关(P>0.05),与白蛋白、肌酐、高密度脂蛋白胆固醇呈显著正相关(P<0.05),与甘油三酯、尿酸、尿素、葡萄糖、血浆硬脂酸(C18:00)、γ-亚麻酸(C18:3n-6)和顺-11-二十烯酸(C20:1n-9)呈显著负相关(P<0.05);睾酮、白蛋白、甘油三酯、硬脂酸(C18:00)在杂食组与素食组间差异无统计学意义(P>0.05)。结论睾酮广泛参与血脂等的代谢,其对甘油三酯水平和血浆硬脂酸(C18:00)含量的影响大于饮食脂肪摄入对其的影响,关注睾酮水平及补充睾酮治疗可能对血脂等代谢相关疾病具有积极意义。

Objective To observe the influence of testosterone level on lipid metabolism in healthy adult males.Methods The levels of lipid and testosterone of 188 healthy adult males(86 vegetarians,102 omnivores)were tested by routine method,and the construction of plasma phospholipid fatty acids was tested by gas chromatographic method.Results Testosterone had no significant correlation with serum total albumin,prealbumin,total cholesterol and low density lipoprotein cholesterol(P>0.05),and significantly positive correlation with albumin,creatinine,and high density lipoprotein cholesterol(P<0.05),while it had negative correlation with triglyceride,uric acid,urea,glucose,plasma stearic acid(C18:00),γ-linolenic acid(C18:3 n-6)and cis-11-Eicosenoic acid(C20:1 n-9)(P<0.05).The differences of testosterone,albumin,triglyceride and stearic acid(C18:00)were not statistically significant between vegetarian group and omnivorous group(P>0.05).Conclusion Testosterone participates in lipid metabolism and influence triglyceride as well as stearic acid(C18:00)deeper than lipid intake.And it will be of high value to pay attention to the testosterone level and testosterone administration for lipid metabolic disorders.