急性颅脑损伤病人血清S-NSE浓度及其与GCS的关系

Significance of serum neuron-specific enolase in assessment of severity of brain damage and its correlation with Glascow Coma Scale score

目的探讨血清神经元特异性烯醇酶(S-NSE)浓度测定对判断急性脑损伤程度的临床价值,及其浓度变化与格拉斯哥昏迷评分(GCS)的相关性。方法对46例急性脑外伤病人(损伤组)和46例排除神经系统疾病的同期住院病人(对照组)在入院时进行GCS评分,入院次日清晨(均在受伤后24h内)采集两组病人静脉血标本,通过酶标法测定血清NSE浓度。结果急性颅脑损伤病人血清NSE浓度显著性高于对照组(P<0.01),且浓度的升高与病情的轻重有关。S-NSE浓度与入院时的GCS呈负相关(r=-0.82,P<0.01)。结论S-NSE浓度是判断急性脑损伤程度的敏感指标,其浓度变化与GCS评分呈负相关。

Objective To explore the clinical implication of serum neuron-specific enolase(S-NSE) content for assessment of the severity of acute brain damage and the correlation between S-NSE content and the GCS score.Methods Forty-six patients with acute head injury and another 46 concurrent patients without neurological diseases were enrolled in this study.The GCS was evaluated on admission.Venous blood samples were obtained from the patients and the control patients to determine S-NSE by means of enzyme-linked immunosorbent assay(ELISA) on the first day after admission,which was in 24 hours after the injury.Results The content of S-NSE in patients with acute head injury was significantly higher than that of the control patients,and the correlation coefficient between the content of S-NSE and GCS score was-0.82(P < 0.01).Conclusion S-NSE is a sensitive index for evaluating the severity of acute brain damage and is in negative correlation with GCS score.