脑室下区胶质瘤病人生存状况的荟萃分析

Survival status of patients with subventricular zone gliomas: a Meta-analysis

目的通过Meta分析研究脑室下区(subventricular zone,SVZ)胶质瘤病人的生存状况。方法检索关于SVZ胶质瘤病人生存状况相关的文献,并按特定纳入标准与排除标准进行筛选。采用纽卡斯尔-渥太华量表对所选文献进行质量评价。使用随机效应模型或固定效应模型Meta分析比较SVZ胶质瘤和非SVZ胶质瘤病人中位生存期(overal survival,OS)和中位无进展生存期(progression free survival,PFS)的差异。结果本研究共纳入相关文献16篇。SVZ胶质瘤病人和非SVZ胶质瘤病人的中位OS分别为12.95个月和16.58个月,中位PFS分别为4.54个月和6.25个月。Meta分析结果显示:SVZ胶质瘤病人中位OS (OR=1.59,95%CI:1.35～1.87,P=0.036)及中位PFS (OR=1.44,95%CI:1.25～1.65,P <0.0001),均明显小于非SVZ胶质瘤。对选用多因素回归分析方法的文献进行亚组分析,亦发现SVZ胶质瘤病人中位OS明显小于非SVZ胶质瘤(OR=1.26,95%CI:1.12～1.42,P <0.0001)。结论 SVZ胶质瘤病人预后明显差于非SVZ胶质瘤病人。SVZ胶质瘤是影响胶质瘤病人预后的重要因素之一。

Objective To investigate t he survival status of patients with subventricular zone( SVZ) gliomas by Meta-analysis.Methods The literature about the survival of SVZ glioma patients was searched according to the specific inclusion and exclusion criteria. The quality of selected literature was evaluated by Newcastle-Ottawa Scale. The differences in median overal survival(OS)and median progression free survival(PFS) between SVZ gliomas and non-SVZ glioma patients were analyzed and compared by Meta-analysis using random-effect model or fixed-effect model. Results A total of 16 literatures were analyzed by Meta-analysis. The median OS of SVZ glioma patients and non-SVZ glioma patients was 12.95 months and 16.58 months, and median PFS was 4.54 months and 6.25 months respectively. Meta-analysis showed that the median OS(OR = 1.59, 95%CI:1.35-1.87, P = 0.036) and median PFS(OR = 1.44, 95%CI: 1.25-1.65, P < 0.0001) of SVZ glioma patients were significantly lower than those in non-SVZ glioma patients. The subgroup analysis showed the median OS of SVZ glioma patients was lower than that of non-SVZ glioma patients(OR =1.26, 95% CI:1.12-1.42, P < 0.0001). Conclusions The prognosis of patients with SVZ glioma is significantly worse than that in non-SVZ glioma. SVZ glioma is one of the important factors affecting the prognosis of glioma patients.