荧光素钠黄荧光显像在高级别胶质瘤手术的应用

Application of fluorescein sodium yellow fluorescence imaging in the surgery of high-grade glioma

目的探讨荧光素钠黄荧光显像在高级别胶质瘤手术的应用价值。方法回顾性分析105例高级别胶质瘤病例资料,以是否使用荧光素钠黄荧光显像分为常规手术组(n=43)和荧光手术组(n=62),比较两组病例的手术时间、出血量、肿瘤全切率、并发症发生率。结果与常规手术组比较,荧光手术组肿瘤全切率高(χ2=6.302,P=0.012),而出血量低(t=2.387,P=0.019)。手术时间、颅内血肿、颅内感染、功能障碍加重在两组间差异均无统计学意义(均P> 0.05)。结论荧光素钠黄荧光显像可分辨高级别胶质瘤边界,减少手术出血量,提高肿瘤全切率。

Objective To explore the application value of fluorescein sodium yellow fluorescence imaging in the surgery of high-grade glioma.Methods The clinical data of 105 patients with high-grade glioma were analyzed retrospectively.According to whether fluorescein sodium yellow fluorescence imaging was used or not,the patients were divided into traditional microsurgical group(n=43)and fluorescein microsurgical group(n=62).The operation time,amount of bleeding,rate of tumor total resection and complication were compared respectively between the two groups.Results Compared with the traditional microsurgical group,the rate of tumor total resection was higher in the fluorescein microsurgical group(χ2=6.302,P=0.012),while the amount of bleeding was lower(t=2.387,P=0.019).There were no significant differences in operation time,intracranial hematoma,intracranial infection and aggravated dysfunction between the two groups(all P>0.05).Conclusions Fluorescein sodium yellow fluorescence imaging can distinguish the boundary of high-grade glioma,reduce the amount of bleeding and improve the rate of tumor total resection.