摘要
苯并(a)芘(BP)是一种在环境中广泛存在的致癌污染物。目前已经证明,BP 进入细胞后需要经过芳烃羟化酶(AHH)和环氧化物水化酶(EH)代谢方可发挥致癌作用。肺脏是大气中污染物进入机体的主要门户。
By the test for Unschedu led DNA synthesis in lymphocytes, the ability of metabolic activation of benzo(a)pyrene (BP) in human lung tissue was studied. The results showed that the effect on the damage of DNA induced through metabolic activation of BP in lung tissue of patients with lung cancer was higher than that of patients without such cancer (0.05<P<0.10). Further experimental works were, however, needed in order to elucidate whether there existed a causuality between the above-mentioned difference and the lung cancers. Among patients with pulmonary diseases, the capacity of metabolic activation of BP by lung tissue of smokers was significantly higher than that of nonsmokers (P<0.002), indicating the acceleration of the activation and the increase in DNA damage of lung tissues by smoking. The results showed that the scope of application of UDS was extended by this experiment from screening carcinogens only to comparison of the difference between various activation systems, This method is feasible.
