麻杏甘石汤加减治疗水痘32例临床观察

Clinical observation of maxingganshi decoction addition and subtraction in the treatment of 32 cases varicella

目的观察麻杏甘石汤加减联合利巴韦林与维生素C治疗小儿水痘的临床疗效。方法治疗组在对照组治疗方法的基础上,加服麻杏甘石汤加减配方颗粒剂,与对照组比较疗效。结果两组患者经5d治疗后,治疗组临床症状改善程度明显优于对照组(96.8%比84.3%),差异有统计学意义(P<0.05)。治疗后,两组患儿的不适症状均有不同程度改善,治疗组恢复情况,明显优于对照组,退热时间[(2.3±0.7)d比(3.5±0.5)d]、疱疹愈合时间[(4.7±0.6)d比(6.4±0.8)d]、皮疹消退时间[(6.2±0.7)d d比(7.5±0.8)d]和住院的平均时间[(5.8±0.8)d比(7.7±0.7)d]均显著短于对照组,差异均有统计学意义(均P<0.05)。两组均无药物相关的不良反应事件发生。部分患儿出现轻度感染,治疗组1例,对照组3例,均未处理,自行缓解,能够继续完成治疗。结论麻杏甘石汤加减联合利巴韦林与维生素C治疗小儿水痘,疗效显著,值得推广。

Objective To observe the clinical efficacy of Maxingganshi decoction addition and subtraction combined with ribavirin and vitamin C in the treatment of varicella in children.Methods On the basis of the treatment method of the control group,the treatment group was treated with Maxing Ganshi Decoction and granules,and the curative effect was compared with the control group.Results After 5 days of treatment,the improvement of clinical symptoms in the treatment group was significantly better than that in the control group(96.8%vs 84.3%),and the difference was statistically significant(P<0.05).After treatment,the discomfort symptoms of the two groups were improved to different extents.The recovery of the treatment group was significantly better than that of the control group.The time of fever[2.3±0.7)d ratio(3.5±0.5)d],herpes healing time[(4.7±0.6)d ratio(6.4±0.8)d],rash regression time[(6.2±0.7)d ratio(7.5±0.8)d]and average hospitalization time[(5.8±0.8)d ratio(7.7±0.7))d]were significantly shorter than the control group,and the differences were statistically significant(P<0.05).There were no drug-related adverse events in both groups.Some children developed mild infection,1 in the treatment group and 3 in the control group,all of which were untreated and resolved spontaneously.Conclusion Ma Xing Gan Shi Decoction combined with ribavirin and vitamin C in the treatment of children with chickenpox,the effect is significant,it is worth promoting.