转化生长因子-β_1和血管紧张素Ⅱ与高血压性肾损害关系的探讨

Relationship between the TGF-β_1,AngⅡchanges and hypertensive kidney lesion

目的通过测定高血压患者血转化生长因子(TGF )- β1和血管紧张素Ⅱ(Ang Ⅱ)水平,进一步探讨TGF-β1和Ang Ⅱ与高血压性肾损害发生、发展的关系。方法将101例原发性高血压病人分为肾损害和无肾损害两组。应用酶联免疫吸附实验(ELISA)和放射免疫法分别测定血清TGF-β1和血浆AngⅡ浓度。结果高血压肾损害组血TGF-β1和AngⅡ水平高于无肾损害组和对照组,差异有显著性,P<0.05;TGF-β1与Ang Ⅱ之间具有相关性,r值为0.536 7,P<0.05。结论血管活性物质TGF-β1和Ang Ⅱ在高血压肾损害的发生过程中起重要的作用。血TGF-β1可作为高血压肾损害的早期诊断指标之一。

Objective The molecular mechanism in hypertensive kidney lesion was demonstrated by monitoring the levels of serum transforming growth factor(TGF)-β 1 and plasma angiotensin(Ang) Ⅱin essential hypertensive patients,now investigating its relationship with hypertensive kidney lesion.Methods One hundred and one patients with essential hyper-tension were divided into two groups according to urine microalbuminuria:with and without kidney lesion.The serum concen-tration of TGF-β 1 was measured by ELISA method; plasma AngⅡwas measured by radioimmunoassay.Results The hy-pertension with kidney lesion group got a higher blood TGF- β 1 and AngⅡlevel than the hypertension without kidney lesion group and the control group did, there was a significant difference (P<0.05); a correlation existed between TGF-β 1 and AngⅡ,r=0.536 7,P<0.05.Conclusion①TGF-β 1 and AngⅡplay an important role in the occurrence and development of hy-pertensive kidney lesion.②TGF-β 1 may act as one of the early diagnostic indices for hypertensive kidney lesion.