摘要
Background. Although previous studies have indicated that serum pepsinogen I levels, as well as the pepsinogen I/II ratio, were positively correlated with maximal gastric output, the relationship may be different between Helicobacter pylori-negative and -positive subjects. The aim of this study was to investigate the relation between serum pepsinogen concentrations and gastric acid secretion in H. pylori-positive and -negative subjects separately. Methods. The presence of H. pylori infection, the serum pepsinogen concentration s, and gastric acid secretion were investigated in 182 subjects without localize d lesions in the upper gastrointestinal tract. Serum pepsinogen concentration wa s measured by radioimmunoassay, and maximal gastric acid output was estimated by an endoscopic gastrin test, as we have previously shown. Results. In H. pylori -positive subjects, serum pepsinogen I levels and the pepsinogen I/II ratio wer e significantly correlated with gastric acid secretion, although the latter show ed a better correlation (r = 0.40 and 0.53, respectively). On the other hand, in H. pylori-negative subjects, serum pepsinogen concentrations were well correla ted with acid secretion (r = 0.57), but there was no relation between the pepsin ogen I/II ratio and acid secretion. Conclusions. The correlations between serum pepsinogens and gastric acid secretion differ, depending on the presence or abse nce of H. pylori infection. With the use of serum pepsinogens as a simple measur e of gastric acid secretion, therefore, consideration of H. pylori infection sta tus is needed. Because the determination of the acid secretory level has some cl inical implications in both H. pylori-positive and -negative subjects, its est imation by serum pepsinogen concentrations can be of practical use.
Background. Although previous studies have indicated that serum pepsinogen I levels, as well as the pepsinogen I/II ratio, were positively correlated with maximal gastric output, the relationship may be different between Helicobacter pylori-negative and -positive subjects. The aim of this study was to investigate the relation between serum pepsinogen concentrations and gastric acid secretion in H. pylori-positive and -negative subjects separately. Methods. The presence of H. pylori infection, the serum pepsinogen concentration s, and gastric acid secretion were investigated in 182 subjects without localize d lesions in the upper gastrointestinal tract. Serum pepsinogen concentration wa s measured by radioimmunoassay, and maximal gastric acid output was estimated by an endoscopic gastrin test, as we have previously shown. Results. In H. pylori -positive subjects, serum pepsinogen I levels and the pepsinogen I/II ratio wer e significantly correlated with gastric acid secretion, although the latter show ed a better correlation (r = 0.40 and 0.53, respectively). On the other hand, in H. pylori-negative subjects, serum pepsinogen concentrations were well correla ted with acid secretion (r = 0.57), but there was no relation between the pepsin ogen I/II ratio and acid secretion. Conclusions. The correlations between serum pepsinogens and gastric acid secretion differ, depending on the presence or abse nce of H. pylori infection. With the use of serum pepsinogens as a simple measur e of gastric acid secretion, therefore, consideration of H. pylori infection sta tus is needed. Because the determination of the acid secretory level has some cl inical implications in both H. pylori-positive and -negative subjects, its est imation by serum pepsinogen concentrations can be of practical use.
