人格障碍遗传流行病学研究(综述)

A review of genetic epidemiology of personality disorder

本文从群体角度,对人格障碍(Personality Disorder,PD)的广义遗传性与家庭环境因素进行回顾,综述了人格障碍发生是遗传因素和环境因素交互作用的结果。研究表明人格障碍的发生有一定的遗传基础,包括家系研究、双生子研究、神经生理研究。另外,环境因素,即社会心理因素在人格障碍的发生、发展过程中也起到不可忽视的作用。总体上人格障碍的发生是遗传因素和环境因素交互作用的结果。本文通过列举对高危型人格障碍的研究,探讨遗传和环境因素在人格障碍发生过程中的相互作用形式及影响大小,为制订人群干预措施进而有效地降低人格障碍的疾病负担提供有效的依据。

This article reviews studies on the heredity of personality disorders and family environment factors from the population-based studies,and summarizes the interaction between genetic factors and environmental factors. Studies have shown that there is a genetic basis for personality disorders,including family studies,twin studies,and neurophysiological studies. In addition, environmental factors, including social psychological factors, also play an important role in the development of personality disorder. In sum,the occurrence of personality disorder is the result of interactions between genetic factors and environmental factors. This paper snmmarizes sresearch on personality disorders,and investigates the role of interaction between genetic and environmental factors in the development of personality disorders. Such evidence has implications for effective prevention and intervention of personality disorders.