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Case-control study of factors that trigger inflammatory bowel disease flares 被引量:2

Case-control study of factors that trigger inflammatory bowel disease flares
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摘要 AIM: To explore the association between inflammatory bowel diseases (IBD) flares and potential triggers. AIM:To explore the association between inflammatory bowel diseases(IBD)flares and potential triggers.METHODS:Patients evaluated for an acute flare of IBD by a gastroenterologist at the Dallas VA Medical Center were invited to participate,as were a control group of patients with IBD in remission.Patients were systematically queried about nonsteroidal anti-inflammatory drug use,antibiotic use,stressful life events,cigarette smoking,medication adherence,infections,and travel in the preceding 3 mo.Disease activity scores were calculated for each patient at the time of enrollment and each patient’s chart was reviewed.Multivariate regression analysis was performed.RESULTS:A total of 134 patients with IBD(63 with Crohn’s disease,70 with ulcerative colitis,and 1 with indeterminate colitis)were enrolled;66 patients had flares of their IBD and 68 were controls with IBD in remission(for Crohn’s patients,average Crohn’s disease activity index was 350 for flares vs 69 in the controls;for UC patients,Mayo score was 7.6 for flares vs 1 for controls in those with full Mayo available and 5.4p for flares vs 0.1p for controls in those with partial Mayo score).Only medication non-adherence was significantly more frequent in the flare group than in the control group(48.5%vs 29.4%,P=0.03)and remained significant on multivariate analysis(OR=2.86,95%CI:1.33-6.18).On multivariate regression analysis,immunomodulator use was found to be associated with significantly lower rates of flare(OR=0.40,95%CI:0.19-0.86).CONCLUSION:In a study of potential triggers for IBD flares,medication non-adherence was significantly associated with flares.These findings are incentive to improve medication adherence.
出处 《World Journal of Gastroenterology》 SCIE CAS 2014年第15期4329-4334,共6页 世界胃肠病学杂志(英文版)
基金 Supported by The Office of Medical Research,Department of Veteran’s Affairs,and in part,by Janssen,Inc
关键词 Inflammatory bowel diseases Flare Non-adherence Crohn&#x02019 s disease Ulcerative colitis Inflammatory bowel diseases Flare Nonadherence Cro
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  • 1Fernando Bermejo,Antonio López-San Román,Alicia Algaba,Iván Guerra,Paz Valer,Silvia García-Garzón,Belén Piqueras,Carlos Villa,Andrea Bermejo,José L. Rodríguez-Agulló.Factors that modify therapy adherence in patients with inflammatory bowel disease[J].Journal of Crohn’s and Colitis.2010(4)
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