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Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet 被引量:7

Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet
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摘要 In the present study we report on changes in irritable bowel syndrome-severity scoring system(IBS-SSS)and irritable bowel syndrome-quality of life(IBS-QoL)in 19 IBS patients,aged 18 to 74 years(F/M:14/5),during 12 wk registering their symptoms on the webapplication(www.ibs.constant-care.dk).During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention.Thereafter,low fermentable oligo-,di-,mono-saccharides and polyols(FODMAP)diet(LFD)was introduced for the next6 wk while continuing the registration.Though a small sample size a significant improvement in disease activity(IBS-SSS)was observed during both the control period,median:278(range:122-377),P=0.02,and subsequently during the LFD period,median:151(range:29-334),P<0.01.The IBS-QoL solely changed significantly during the LFD period,median:67(37-120),P<0.01.The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a"traffic light".However adding the diet reduced IBSSSS to<150,inactive to mild symptoms.In the future results from larger scale trials are awaited. In the present study we report on changes in irritable bowel syndrome-severity scoring system (IBS-SSS) and irritable bowel syndrome-quality of life (IBS-QoL) in 19 IBS patients, aged 18 to 74 years (F/M: 14/5), during 12 wk registering their symptoms on the web-application (www.ibs.constant-care.dk). During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention. Thereafter, low fermentable oligo-, di-, mono-saccharides and polyols (FODMAP) diet (LFD) was introduced for the next 6 wk while continuing the registration. Though a small sample size a significant improvement in disease activity (IBS-SSS) was observed during both the control period, median: 278 (range: 122-377), P = 0.02, and subsequently during the LFD period, median: 151 (range: 29-334), P &#x0003c; 0.01. The IBS-QoL solely changed significantly during the LFD period, median: 67 (37-120), P &#x0003c; 0.01. The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a &#x0201c;traffic light&#x0201d;. However adding the diet reduced IBS-SSS to &#x0003c; 150, inactive to mild symptoms. In the future results from larger scale trials are awaited.
出处 《World Journal of Gastroenterology》 SCIE CAS 2014年第21期6680-6684,共5页 世界胃肠病学杂志(英文版)
关键词 IRRITABLE BOWEL syndrome LOW fermentable oligo- di Irritable bowel syndrome Low fermentable oligo- di- mono-saccharides and polyols diet Self-management Disease-specific quality of life Disease activity
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  • 1Philip Hilgard,Alisan Kahraman,Nils Lehmann,Cornelia Seltmann,Susanne Beckebaum,R Stefan Ross,Hideo A Baba,Massimo Malago,Christoph E Broelsch,Guido Gerken.Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis[J].World Journal of Gastroenterology,2006,12(5):697-702. 被引量:235
  • 2J. W. Berrill,J. T. Green,K. Hood,A. K. Campbell.Symptoms of irritable bowel syndrome in patients with inflammatory bowel disease: examining the role of sub‐clinical inflammation and the impact on clinical assessment of disease activity[J].Aliment Pharmacol Ther.2013(1)
  • 3Alexander C Ford,Nicholas J Talley.Irritable bowel syndrome[J].BMJ (sep ).2012(sep041)
  • 4R. H. Roest,B. R. Dobbs,B. A. Chapman,B. Batman,L. A. O’Brien,J. A. Leeper,C. R. Hebblethwaite,R. B. Gearry.The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study[J].Int J Clin Pract.2013(9)
  • 5J. S.BARRETT,R. B.GEARRY,J. G.MUIR,P. M.IRVING,R.ROSE,O.ROSELLA,M. L.HAINES,S. J.SHEPHERD,P. R.GIBSON.Dietary poorly absorbed, short‐chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon[J].Alimentary Pharmacology & Therapeutics.2010(8)
  • 6Susan J. Shepherd,Francis C. Parker,Jane G. Muir,Peter R. Gibson.Dietary Triggers of Abdominal Symptoms in Patients With Irritable Bowel Syndrome: Randomized Placebo-Controlled Evidence[J].Clinical Gastroenterology and Hepatology.2008(7)
  • 7Susan J. Shepherd,Peter R. Gibson.Fructose Malabsorption and Symptoms of Irritable Bowel Syndrome: Guidelines for Effective Dietary Management[J].Journal of the American Dietetic Association.2006(10)
  • 8C. Y.FRANCIS,J.MORRIS,P. J.WHORWELL.The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress[J].Alimentary Pharmacology & Therapeutics.2003(2)
  • 9Donald L. Patrick,Douglas A. Drossman,Ihunnaya O. Frederick,Joseph Dicesare,Katherine L. Puder.Quality of Life in Persons with Irritable Bowel Syndrome (Development and Validation of a New Measure)[J].Digestive Diseases and Sciences.1998(2)
  • 10Jacqueline S. Barrett,Peter R. Gibson.Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals?[J].Therapeutic Advances in Gastroenterology.2012(4)

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