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Hepatitis C-associated liver carcinogenesis:Role of PML nuclear bodies 被引量:1

Hepatitis C-associated liver carcinogenesis:Role of PML nuclear bodies
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摘要 Successful escape from immune response characterises chronic hepatitis C virus (HCV) infection, which results in persistence of infection in about 80% of the patients. The deleterious consequences are cirrhosis and hepatocellular carcinoma. HCV accounts the most frequent cause for hepatocellular carcinoma (HCC) and liver transplantation (LT) in the western world. The underlying molecular mechanisms how HCV promotes tumor development are largely unknown. There is some in vitro and in vivo evidence that HCV interferes with the tumor suppressor PML and may thereby importantly contribute to the HCV-associated pathogenesis with respect to the development of HCC. The tumor suppressor protein “promyelocytic leukemia” (PML) has been implicated in the regulation of important cellular processes like differentiation and apoptosis. In cancer biology, PML and its associated nuclear bodies (NBs) have initially attracted intense interest due to its role in the pathogenesis of acute promyelocytic leukemia (APL). More recently, loss of PML has been implicated in human cancers of various histologic origins. Moreover, number and intensity of PML-NBs increase in response to interferons (IFNs) and there is evidence that PML-NBs may represent preferential targets in viral infections. Thus, PML could not only play a role in the mechanisms of the antiviral action of IFNs but may also be involved in a direct oncogenic effect of the HCV on hepatocytes. This review aims to summarise current knowledge about HCV-related liver carcinogenesis and to discuss a potential role of the nuclear body protein PML for this this hard-to-treat cancer. Successful escape from immune response characterises chronic hepatitis C virus(HCV) infection,which results in persistence of infection in about 80% of the patients.The deleterious consequences are cirrhosis and hepatocellular carcinoma.HCV accounts the most frequent cause for hepatocellular carcinoma(HCC) and liver transplantation(LT) in the western world.The underlying molecular mechanisms how HCV promotes tumor development are largely unknown.There is some in vitro and in vivo evidence that HCV interferes with the tumor suppressor PML and may thereby importantly contribute to the HCV-associated pathogenesis with respect to the development of HCC.The tumor suppressor protein "promyelocytic leukemia"(PML) has been implicated in the regulation of important cellular processes like differentiation and apoptosis.In cancer biology,PML and its associated nuclear bodies(NBs) have initially attracted intense interest due to its role in the pathogenesis of acute promyelocytic leukemia(APL).More recently,loss of PML has been implicated in human cancers of various histologic origins.Moreover,number and intensity of PML-NBs increase in response to interferons(IFNs) and there is evidence that PML-NBs may represent preferential targets in viral infections.Thus,PML could not only play a role in the mechanisms of the antiviral action of IFNs but may also be involved in a direct oncogenic effect of the HCV on hepatocytes.This review aims to summarise current knowledge about HCV-related liver carcinogenesis and to discuss a potential role of the nuclear body protein PML for this this hard-to-treat cancer.
出处 《World Journal of Gastroenterology》 SCIE CAS 2014年第35期12367-12371,共5页 世界胃肠病学杂志(英文版)
关键词 Hepatitis C virus Promyelocytic leukemia Nuclear bodies Hepatocellular carcinoma APOPTOSIS Hepatitis C virus Promyelocytic leukemia Nuclear b
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  • 1Denis Selimovic,Abdelouahid El-Khattouti,Hanan Ghozlan,Youssef Haikel,Ola Abdelkader,Mohamed Hassan.Hepatitis C virus-related hepatocellular carcinoma:An insight into molecular mechanisms and therapeutic strategies[J].World Journal of Hepatology,2012,4(12):342-355. 被引量:7
  • 2Andreas Teufel,Frank Staib,Stephan Kanzler,Arndt Weinmann,Henning Schulze-Bergkamen,Peter R Galle.Genetics of hepatocellular carcinoma[J].World Journal of Gastroenterology,2007,13(16):2271-2282. 被引量:22
  • 3Yih‐Lin Chung,Mei‐Ling Wu.Promyelocytic leukaemia protein links DNA damage response and repair to hepatitis B virus‐related hepatocarcinogenesis[J].J Pathol.2013(4)
  • 4Massimo Colombo,Jean-Luc Raoul,Riccardo Lencioni,Peter R. Galle,Jessica Zucman-Rossi,Rafael Ba?ares,Daniel Seehofer,Peter Neuhaus,Philip Johnson.Multidisciplinary strategies to improve treatment outcomes in hepatocellular carcinoma: a European perspective[J].European Journal of Gastroenterology & Hepatology.2013(6)
  • 5Jiang Long,Yan Wang,Man Li,Wei-Min Tong,Ji-Dong Jia,Jian Huang.Correlation of TP53 mutations with HCV positivity in hepatocarcinogenesis:Identification of a novel TP53 microindel in hepatocellular carcinoma with HCVinfection[J].Oncology Reports.2013(1)
  • 6Carracedo, Arkaitz,Weiss, Dror,Leliaert, Amy K,Bhasin, Manoj,de Boer, Vincent C J,Laurent, Gaelle,Adams, Andrew C,Sundvall, Maria,Song, Su Jung,Ito, Keisuke,Finley, Lydia S,Egia, Ainara,Libermann, Towia,Gerhart-Hines, Zachary,Puigserver, Pere,Haigis, Marcia C,Maratos-Flier, Elefteria,Richardson, Andrea L,Schafer, Zachary T,Pandolfi, Pier P.A metabolic prosurvival role for PML in breast cancer[J].EN.2012(9)
  • 7Augusto Villanueva,Xavier Forns,Josep M. Llovet.Molecular epidemiology in HCV-related hepatocellular carcinoma: First steps[J].Journal of Hepatology.2012(1)
  • 8Shah Jahan,Usman A. Ashfaq,Saba Khaliq,Baila Samreen,Nadeem Afzal.Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC[J].Infection Genetics and Evolution.2012(2)
  • 9Andreas Teufel,Jens U. Marquardt,Peter R. Galle.Novel insights in the genetics of HCC recurrence and advances in transcriptomic data integration[J].Journal of Hepatology.2011(1)
  • 10Jamila El Bougrini,Laurent Dianoux,Mounira K. Chelbi-Alix.PML positively regulates interferon gamma signaling[J].Biochimie.2010(3)

二级参考文献207

  • 1Lian-YueYang WeiWang Ji-XiangPeng Jie-QuanYang Gen-WenHuang.Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma[J].World Journal of Gastroenterology,2004,10(24):3569-3573. 被引量:4
  • 2Jun Dou,Pengbo Liu,Jing Wang,Xinjian Zhang.Preliminary Analysis of Gene Expression Profiles in HepG2 Cell Line Induced by Different Genotype Core Proteins of HCV[J].Cellular & Molecular Immunology,2006,3(3):227-233. 被引量:2
  • 3Majumder M,Ghosh A K,Steele R,et al.Hepatitis C virus NS5A physically associates with p53 and regulates p21/wafl gene expression in a p53-dependent mannerJournal of Virology,2001.
  • 4Thirunavukkarasu C,Watkins S,Harvey SA,et al.Superoxide-induced apoptosis of activated rat hepatic stellate cellsJournal of Hepatology,2004.
  • 5Butcher E;Picker L.Lymphocyte homing and homeostasis,1996(05).
  • 6Yoshida H;Onda M;Tajiri T;Umehara M,Mamada Y,Matsumoto S,Yamomoto K,Kaneko M,Kumazaki T.Treatment of spontaneous ruptured hepatocellular carcinoma,1999.
  • 7Moriya K,Fujie H,Shintani Y,Yotsuyanagi H,Tsutsumi T,Ishibashi K,Matsuura Y,Kimura S,Miyamura T,Koike K.The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nature Medicine . 1998
  • 8Asakawa M,Kono H,Amemiya H,Matsuda M,Suzuki T,Maki A,Fujii H.Role of interleukin-18 and its receptor in hepatocellular carcinoma associated with hepatitis C virus infection. International Journal of Cancer . 2006
  • 9Mika Miura,Shinya Maekawa,Makoto Kadokura,Ryota Sueki,Kazuki Komase,Hiroko Shindo,Takako Ohmori,Asuka Kanayama,Kuniaki Shindo,Fumitake Amemiya,Yasuhiro Nakayama,Takatoshi Kitamura,Tomoyoshi Uetake,Taisuke Inoue,Minoru Sakamoto,Shunichi Okada,Nobuyuki Enomoto.Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C[J]. Hepatology International . 2012 (1)
  • 10Cansel Türkay,?zlem Y?nem,Sema Ar?c?,Ayhan Koyuncu,Mehmet Kanbay.Effect of Angiotensin-converting Enzyme Inhibition on Experimental Hepatic Fibrogenesis[J]. Digestive Diseases and Sciences . 2008 (3)

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