摘要
AIM:To investigate the effect of perioperative restricted fluid therapy on circulating CD4+/CD8+T lymphocyte ratio,percentage of regulatory T cells(Treg)and postoperative complications in patients with colorectal cancer.METHODS:A total of 185 patients met the inclusion criteria and were included in the randomized clinical trial.These patients were divided into two groups according to receipt of either perioperative standard(S,n=89)or restricted(R,n=96)fluid therapy.Clinical data of these patients were collected in this prospective study.Perioperative complications and cellular immunity changes(CD4+/CD8+and Treg)were analyzed comparatively between the two groups.RESULTS:Both during surgery and on postoperativedays,the total volumes of fluids administered in the R group were significantly lower than those in the S group(1620±430 mL vs 3110±840 mL;2090±360mL vs 2750±570 mL;1750±260 mL vs 2740±490mL;1620±310 mL vs 2520±300 mL;P<0.05).Decreased ratios of circulating CD4+/CD8+T lymphocytes(1.47±0.28 vs 2.13±0.26;1.39±0.32 vs 2.21±0.24;P<0.05)and Treg percentage values(2.79±1.24vs 4.26±1.04;2.46±0.98 vs 4.30±1.12;P<0.05)were observed after surgery in both groups.However,in the R group,these values restored more quickly starting from postoperative day 2(1.44±0.24 vs 1.34±0.27;2.93±1.08 vs 2.52±0.96;P<0.05).The proportion of patients with complications was significantly lower in the restricted group(36 of 89 vs 59 of 96,P<0.01).CONCLUSION:Perioperative restricted intravenous fluid regimen leads to a low postoperative complication rate and better cellular immunity preservation in patients with colorectal cancer.
AIM: To investigate the effect of perioperative restricted fluid therapy on circulating CD4<sup>+</sup>/CD8<sup>+</sup> T lymphocyte ratio, percentage of regulatory T cells (Treg) and postoperative complications in patients with colorectal cancer.
