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^(89)Zr标记抗体PET显像技术在药物研发中的应用 被引量：1

Application of PET with ^(89)Zr labeled antibodies in drug research and development
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摘要 ^(89)Zr标记抗体正电子成像术(PET)显像可实时可视化提供抗体在生物体内药物代谢动力学特征,同时可在疗效监测、安全性预估、患者筛选、剂量指导等方面提供客观依据,作为常规抗体药物研发方法的有效补充,加之其高分辨率、高灵敏度、自身对照以及可定量等特点,已被应用于抗体药物的研发。本文综述了PET显像、^(89)Zr、抗体及^(89)Zr标记后PET显像应用等方面的研究现状,并对^(89)Zr标记PET显像在抗体药物研发中的应用前景进行了展望。 Position emission tomography(PET)with 89Zr-labeled antibodies can provide real-time visualized information of the pharmacokinetics characteristic of antibodies in vivo as well as efficacy monitoring,safety estimation,patient stratification,planning of radioimmunotherapy and so on.As an effective supplement method to conventional antibodies development and in addition to the characteristics of high resolution,high sensitivity,self-control and quantifiability,it has been already applied to the research and development of antibody drugs.This review summarized the research progress in PET,isotope 89Zr,antibodies,and provided many appealing examples of PET with 89Zr-labeled antibodies,while future directions are outlined.
作者 王燕 杨敏 缪丽燕 WANG Yan;YANG Min;MIAO Li-yan(Department of Clinical Pharmacology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;College of Pharmacy,Soochow University,Suzhou 215000,China;Molecular Imaging Centre,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China)
机构地区 苏州大学附属第一医院临床药理室 苏州大学药学院 江苏省原子医学研究所分子影像中心
出处 《中国新药杂志》 CAS CSCD 北大核心 2019年第8期954-960,共7页 Chinese Journal of New Drugs
关键词 89Zr 正电子成像术 抗体 药物研发 应用 89Zr position emission tomography antibody drug development application
分类号 R91 [医药卫生—药学]
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共引文献39

同被引文献5

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中国新药杂志
2019年 第8期

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