PDZ结构域有望成为新药靶点

PDZ domains can serve as a target for developing new drugs

PDZ结构域是蛋白质中最常见的肽结合区域之一,它涉及许多关键信号通路。以突触后致密蛋白-95(PSD-95) PDZ结构域为靶点,设计合成的Tat-NR2B9C和ZL006,显示神经保护活性;以神经元型一氧化氮合酶(nNOS) PDZ结构域为靶点,设计合成的ZLc-002,显示抗焦虑活性。本文重点介绍PDZ结构域的结构、分类及有望以含PDZ结构域的蛋白为靶点开发出治疗急性缺血性脑卒中和焦虑症的新药。

PDZ domains,which involve many key signaling pathways,are one of the most common peptide binding domains in proteins.Postsynaptic density protein-95(PSD-95)containing PDZ domains can serve as a target for designing and synthesizing Tat-NR2 B9 C and ZL006 which display potent neuroprotective activity.Neuronal nitric oxide synthase(nNOS)containing PDZ domains can serve as a target for designing and synthesizing ZLc-002 which has antianxiety activity.This review focuses on the structure,classification and the potential design of new drugs for the treatment of acute ischemic stroke and anxiety by targeting proteins containing PDZ domains.