幽门螺杆菌相关性十二指肠溃疡与胃肠激素的关系

Study on the relationship between Heficobacter Pylori-positive duodenal ulcer and gastrointestinal hor- mones

目的探讨幽门螺杆菌(Hp)相关性十二指肠溃疡(DU)患者 Hp 根除前后胃黏膜及血中促胃液素(Gas)和生长抑素(SS)含量变化的意义。方法采用放射免疫分析法测定 Hp 相关性 DU 患者42例 Hp 根除前后及正常对照者20例胃黏膜及血中 Gas 和 SS 含量。结果 Hp 相关性 DU 的患者胃黏膜及血中 Gas 的含量明显高于 Hp 阴性患者(黏膜:ng/g,226±65 vs 38±98;血清:ng/L,107±33 vs 50±8);而 Hp 根除后 Gas 含量明显下降。Hp 阳性者 SS 的含量低于 Hp 阴性患者(黏膜:ng/g,11±2 vs 42±8;血浆:ng/L,5.6±1.2 vs 10.2±2.3);Hp 根除后 SS 含量显著升高。Hp 感染时胃黏膜炎细胞浸润程度对 Gas 和 SS 的含量亦有一定影响。结论 Gas 和 SS 与 Hp 相关性是参与 DU 发病的重要因素之一。

Obiective To investigate the significance of variation of Gastrin(GaS)and somatostatin(SS)in gastric mucosa and blood of patients with Hp-positive duodenal ulcer(DU),before and after successful eradication of Hp.Methods radio-immunity analysis was used to detect the contents of Gas and SS in gastric mucosa and blood in 42 patients with Hp-Positive DU before and after successful eradiction of HP and 20 normal persons. Results Content of Gas in the Hp-positive group was significantly higher than Hp-negative group(mucosa:ng/g, 226+65 VS 380+98;serum:ng/L,107±33 vs.50±8)and became normal after Hp eradication.The contents of SS in Hp-positive group was significantly lower than Hp-negative groug(mucosa:ng/g,11±2Vs42±8;plasma:ng/L,5.6± 1.2VS 10.24～2.3)and became normal after Hp eradication.On the other hand,content of Gas and SS in nmcosa significantly altered with chronic and active inflammations.Conclusion Gas and SS are related closely to DU and play an important role in the development of DU.