(Z)-1-溴-2-甲基-1-丁烯的合成

Synthesis of (Z)-1-bromo-2-methyl-1-butene

以丁酮为原料,与由亚磷酸三乙酯和氯乙酸乙酯反应得到的二乙氧基磷酰基乙酸乙酯进行Wittig-Horner反应后,再经碱性水解、溴加成反应和脱溴脱羧反应制得(Z)-1-溴-2-甲基-1-丁烯,总收率53.2%(以丁酮计)。

Z)-1-Bromo-2-methyl-1-butene was synthesized by Wittig-Horner reaction from butanone with(diethoxyphosphoryl)acetic acid ethyl ester prepared from phosphorous triethyl ester and ethyl chloroacetate followed byalkali hydrolysis, alkenyl addition of bromine and debrominative decarboxylation with an overall yield of 53.2% (base onbutanone).