炎性因子IL-1β与出血性脑水肿形成的相关性研究

Correlation Study of Inflammatory Factor IL-1β with Hemorrhagic Brain Edema

目的:探究炎性因子IL-1β与出血性脑水肿形成的相关性。方法:选取2017年4月-2018年8月出血性脑水肿形成患者240例。按出血性脑水肿形成患者出血时间分为8、16、24、48、72、120 h组,各40例,并选取200例同期非出血性脑水肿的脑损伤患者作为对照组。比较各组脑水肿体积、血清IL-1β水平,探讨IL-1β与出血性脑水肿形成的相关性。结果:各组脑水肿体积、血清IL-1β水平比较,差异均有统计学意义(P<0.05),其中8～72 h组随着时间的延长,患者脑水肿体积、血清IL-1β水平越高,120 h脑水肿体积、血清IL-1β水平均低于72 h,总体均呈逐渐上升至顶峰后逐渐下降的趋势;经线性回归分析后发现,IL-1β与出血性脑水肿呈正相关(r=0.573,P<0.05)。结论:炎性因子IL-1β与出血性脑水肿形成呈正相关,临床可通过检测IL-1β指标来判断患者脑水肿情况,可为临床选择手术还是保守治疗提供辅助判定依据,此方法值得应用与推广。

Objective:To explore the correlation of inflammatory factor IL-1β with hemorrhagic brain edema.Method:A total of 240 hemorrhagic brain edema patients treated in our hospital from April 2017 to August2018 were selected.According to the time of hemorrhage,they were were divided into 8,16,24,48,72 and120 h groups,40 cases in each group,and 200 cases of non-hemorrhagic brain edema patients in the same period were selected as control group.The volume of brain edema and the level of serum IL-1β in each group were compared,the correlation between IL-1β and the formation of hemorrhagic brain edema was analyzed.Result:The volume of brain edema and the level of serum IL-1β in each group were compared,the differences were statistically significant(P<0.05),the volume of brain edema and the level of serum IL-1β increased with the prolongation of time in the 8-72 h group,while the volume of brain edema and the level of serum IL-1β at 120 h group were lower than 72 h group,and the overall trend was gradually rising to the peak and then gradually declining.Linear regression analysis showed that IL-1β was positively correlated with hemorrhagic brain edema(r=0.573,P<0.05).Conclusion:Inflammatory factor IL-1β is positively correlated with the formation of hemorrhagic brain edema.Clinical examination of IL-1β can be used to determine the condition of brain edema in patients.It can provide an auxiliary basis for clinical selection of surgery or conservative treatment.This method is worthy of application and promotion.