联合检测血清TNF-α、cTnI评估风湿性心脏病的心功能关系

Assessment of Cardiac Function in Patients with Rheumatic Heart Disease by Combined Detection of Serum TNF-α and cTnI

目的:探讨联合检测血清肿瘤坏死因子α(TNF-α)、肌钙蛋白I(cTnI)与评估风湿性心脏病心功能的关系。方法:选取2016年6月-2018年6月本院收治的风心病患者80例为风心组,选取同期健康人员30例为健康组,均检测血清TNF-α、cTnI水平,分析其与患者心功能的关系。结果:风心组血清TNF-α、cTnI水平均高于健康组(P<0.05);风心组中NYHA心功能Ⅳ级患者血清TNF-α、cTnI水平明显高于Ⅱ、Ⅲ级患者,Ⅲ级患者血清TNF-α、cTnI水平明显高于Ⅱ级患者,差异均有统计学意义(P<0.05);Spearman相关性分析结果显示,TNF-α、cTnI与NYHA心功能分级均呈正相关(P<0.001)。结论:血清TNF-α、cTnI水平均与风心病的发生发展有关,血清TNF-α、cTnI水平的联合检测可作为评估患者心功能的重要方法。

Objective:To explore the relationship between serum TNF-αand cTnI levels and cardiac function in patients with rheumatic heart disease.Method:A total of 80 patients with rheumatic heart disease admitted to our hospital from June 2016 to June 2018 were selected as the rheumatic heart disease group,and 30 healthy persons in the same period were selected as the healthy group.Serum levels of TNF-αand cTnI were detected and their relationship with cardiac function was analyzed.Result:The serum levels of TNF-αand cTnI in rheumatic heart disease group were higher than those of healthy group(P<0.05).The serum levels of TNF-αand cTnI in patients with NYHA heart functionⅣgrade were significantly higher than those of Ⅱand Ⅲ grades,and the serum levels of TNF-αand cTnI inⅢgrade were significantly higher than those of Ⅱ grade,the differences were statistically significant(P<0.05).Spearman correlation analysis showed that TNF-αand cTnI were positively correlated with NYHA cardiac function classification(P<0.001).Conclusion:Serum levels of TNF-αand cTnI are related to the occurrence and development of rheumatic heart disease,detection of serum levels of TNF-αand cTnI can be used as an important method to evaluate the cardiac function of patients.