和胃解逆汤治疗便秘型肠易激综合征对血清5-羟色胺和降钙素基因相关肽的影响

Effect of Hewei Jieni Decoction on Serum 5-hydroxytryptamine and Calcitonin Gene-related Peptide in Constipation-predominant Irritable Bowel Syndrome

目的:探讨和胃解逆汤治疗便秘型肠易激综合征(IBS-C)对血清5-羟色胺(5-HT)和降钙素基因相关肽(CGRP)的影响。方法:选取2016年3月-2018年6月本院收治的IBS-C患者80例,依据随机数字表法分为双药组和单药组,每组40例。单药组给予马来酸曲美布汀治疗,双药组在此基础上给予和胃解逆汤治疗,比较两组血清5-HT、CGRP和临床症状、疗效、不良反应。结果:治疗3 d后,两组血清5-HT、CGRP水平均明显低于治疗前,且双药组治疗3 d后血清5-HT、CGRP水平均明显低于单药组,差异均有统计学意义(P<0.05)。治疗3 d后,两组腹胀腹痛、便秘等症状评分均明显低于治疗前,且双药组治疗3 d后腹胀腹痛、便秘等症状评分均明显低于单药组,差异均有统计学意义(P<0.05)。双药组治疗总有效率明显高于单药组,差异有统计学意义(χ~2=7.813,P=0.003)。两组不良反应发生率比较,差异无统计学意义(χ~2=0.105,P=0.745)。结论:和胃解逆汤治疗可有效改善IBS-C患者血清5-HT、CGRP和腹胀腹痛、便秘等症状,有利于提高治疗效果,且安全性好,值得临床推广。

Objective:To discuss the effect of Hewei Jieni Decoction on serum 5-hydroxytryptamine and calcitonin gene-related peptide in the treatment of constipation-predominant irritable bowel syndrome(IBS-C).Method:80 patients with IBS-C were selected from March 2016 to June 2018 in our hospital,according to the random number table,the patients were divided into double drug group and single drug group,with 40 cases in each group.Single drug group was treated with Trimebutine Maleate,and double drug group was treated with Hewei Jieni Decoction.Serum 5-HT,CGRP and clinical symptoms,efficacy and adverse reactions were compared between the two groups.Result:After treatment for 3 days,serum 5-HT and CGRP levels in both groups were significantly lower than those before treatment,serum 5-HT and CGRP levels in the double drug group were significantly lower than those in the single drug group,with statistically significant differences(P<0.05).After treatment for 3 days,the scores of symptoms such as abdominal distension,pain and constipation in both groups were significantly lower than those before treatment,and the scores of symptoms such as abdominal distension,pain and constipation in the double drug group were significantly lower than those in the single drug group,with statistically significant differences(P<0.05).The total effective rate of the double drug group was significantly higher than that of the single drug group,the difference was statistically significant( χ~2=7.813,P=0.003).There was no statistically significant difference in the incidence of adverse reactions between the two groups( χ~2=0.105,P=0.745).Conclusion:Hewei Jieni Decoction can effectively improve serum 5-HT,CGRP,abdominal distension,abdominal pain,constipation and other symptoms of patients with IBS-C,which is conducive to improve the treatment effect,and has good safety,worthy of clinical promotion.