早期唐氏筛查相关血液指标对妊娠结局的反应意义研究

Study on the Response Significance of Early Down's Screening Related Blood Indexes for the Pregnancy Outcome

目的:研究与分析早期唐氏筛查相关血液指标对妊娠结局的反应意义。方法:选取2016年10月—2018年9月8 800例早期唐氏筛查孕妇为研究对象,将其进行唐氏筛查相关血液指标(血清AFP、β-hCG及uE3)的检测,比较不同血清AFP、β-hCG及uE3检测结果者的妊娠结局,并以多因素Logistic回归分析处理上述血清AFP、β-hCG及uE3指标与妊娠结局的关系。结果:异常血清AFP、β-hCG及uE3孕妇妊娠期的异常率与胎儿异常发生率均高于正常检测结果的孕妇,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,血清AFP、β-hCG及uE3与妊娠结局有密切的关系。结论:早期唐氏筛查相关血液指标对妊娠结局的反应意义较高,具有较高的临床检测价值。

Objective:To study and analyze the response significance of early Down’s screening related blood indexes for the pregnancy outcome.Method:8 800 pregnant women during the time of October 2016 to September 2018 were selected as the study objects.The Down’s screening related blood indexes(serum AFP,β-hCG and uE3)were measured.The pregnancy outcome of pregnant women with different detection results of AFP,β-hCG and uE3 were compared,the relationship between serum AFP,β-hCG and uE3 and pregnancy outcome were analyzed with multivariate Logistic regression analysis.Result:The pregnancy abnormality rate and fetal abnormality rate of pregnant women with abnormal serum AFP,β-hCG and uE3 were higher than those of pregnant women with normal test results,the differences were statistically significant(P<0.05).The multivariate Logistic regression analysis showed the serum AFP,β-hCG and uE3 all had close relationship to the pregnancy outcome.Conclusion:The early Down’s screening related blood indexes have higher significance in response to pregnancy outcome and have higher clinical detection value.