温和艾灸寒湿痹阻型类风湿关节炎的疗效和对免疫学的影响

Effect of Mild Moxibustion on Rheumatoid Arthritis with Cold-dampness Obstruction Type and Its Influence on Immunology

目的:观察温和艾灸寒湿痹阻型类风湿关节炎(RA)的疗效和对免疫学的影响。方法:选择2014年1月-2018年1月本院风湿免疫科收治的寒湿痹阻型RA患者500例,按照随机数字表法分为对照组(n=250)与艾灸组(n=250)。对照组给予常规治疗,艾灸组在对照组基础上配合温和艾灸治疗。对比两组治疗前后临床症状改善情况、CRP水平、ESR水平、免疫指标(IgG、IgM、IgA、CD4^+/CD8^+)及临床治疗效果。结果:治疗前两组关节肿胀个数、关节压痛个数、晨僵持续时间、CRP水平、ESR水平、免疫指标水平比较,差异均无统计学意义(P>0.05);治疗后艾灸组关节肿胀个数、关节压痛个数、晨僵持续时间均明显少于对照组,CRP、ESR水平均明显低于对照组,免疫反应指标水平均明显高于对照组,艾灸组总有效率(98.40%)优于对照组(85.20%),两组比较差异均有统计学意义(P<0.05)。结论:在寒湿痹阻型RA的治疗中,采取温和艾灸治疗,可明显减轻临床症状,降低CRP、ESR水平,提升机体内免疫指标水平,提高临床治疗效果。

Objective:To observe the curative effect of Mild Moxibustion on rheumatoid arthritis(RA of cold-dampness obstruction type and its influence on immunology.Method:A total of 500 patients with RA diagnosed as Cold-dampness Obstruction type treated in our hospital from January 2014 to January 2018 were selected.They were randomly divided into the control group(n=250)and Moxibustion group(n=250).The control group was treated with routine treatment,Moxibustion group was treated with Mild Moxibustion on the basis of the control group.The improvement of clinical symptoms,CRP and ESR levels,immune indexes(IgG,IgM,IgA,CD4^+/CD8^+)and clinical efficacy of two groups were compared.Result:There were no significant differences in the number of joint swelling,tenderness,duration of morning stiffness,CRP,ESR and immune response index between two groups before treatment(P>0.05).After treatment,the number of joint swelling,tenderness and morning stiffness in Moxibustion group were significantly less than those in the control group,the levels of CRP and ESR in Moxibustion group were significantly less than those in the control group,the level of immune response index in Moxibustion group were significantly higher than those in the control group,the total effective rate of Moxibustion group(98.40%)was better than that of control group(85.20%),the difference was statistically significant(P<0.05).Conclusion:Mild Moxibustion can obviously relieve the clinical symptoms,reduce the levels of CRP and ESR,improve the level of immune indexes in patients with RA of cold-dampness obstruction type,and improve the therapeutic effect.