本地区妊娠晚期妇女B族链球菌带菌率及相关因素分析

Analysis of Streptococcus B Carrier Rate and Related Factors in Women with Late Pregnancy in Local District

目的:探明本地区妊娠晚期妇女B族链球菌(GBS)带菌率及相关因素分析。方法:将本院2017年11月-2018年10月入住或检查的病患进行统计,筛选出1308例妊娠晚期(34~37周)孕妇为研究对象,均给予荧光定量PCR技术判定GBS带菌率,采用多因素Logistic回归对影响因素进行分析。比较不同年龄、体重指数(BMI)、文化程度、高血压、有无念珠菌性阴道炎(VVC)、有无妊娠期糖尿病(GDM)、有无妊娠晚期性生活和分娩相关因素(流产史、分娩史、阴道分娩史)妊娠晚期孕妇GBS带菌率,并进行危险因素分析,对比检测结果的差异性。结果:经统计,本地区1 308例妊娠晚期孕妇的GBS带菌率为8.7%,35~39岁年龄段的带菌率(12.6%)最高,但不同年龄段的妊娠晚期孕妇带菌率比较,差异无统计学意义(P>0.05)。不同年龄、文化程度、高血压妊娠晚期孕妇带菌率比较,差异均无统计学意义(P>0.05)。不同BMI、有无GDM、VVC、妊娠晚期性生活、流产史、分娩史、阴道分娩史妊娠晚期孕妇带菌率比较,差异均有统计学意义(P<0.05)。BMI、GDM、VVC、妊娠晚期性生活、分娩史、阴道分娩史、流产史均是妊娠晚期孕妇GBS带菌率的独立危险因素(P<0.05)结论:年龄及高血压等与带菌率的相关性较小,妊娠晚期孕妇感染B族链球菌危险因素有BMI、GDM、VVC、流产史、阴道分娩史、妊娠晚期性生活等,可通过采取相应的预防措施来降低病发率。

Objective:To investigate the carrierrate of streptococcus B(GBS)and its related factors in women with late pregnancy in local district.Method:The patients admitted or examined in our hospital from November 2017 to October 2018 were counted,and 1308 cases of late pregnancy women(34 to 37 weeks)were selected as the study subjects.All of them were given quantitative fluorescence PCR to determine the carrierrate of GBS,and multivariate Logistic regression was used to analyze the influencing factors.The GBS carrier rate of women with late pregnancy was compared among different ages,body mass index(BMI),education level,hypertension,presence or absence of candida vaginitis(VVC),presence or absence of gestational diabetes mellitus(GDM),presence or absence of sexual life and related factors of delivery in the third trimester(history of abortion,history of delivery,history of vaginal delivery).And the risk factors were analyzed and differences of test results were compared.Result:According to the statistics,the GBS carrier rate of 1 308 women with late pregnancy was 8.7%.The highest carrier rate(12.6%)was found in the age group of 35 to 39 years.However,there was no statistically significant difference in the carrier rate of women with late pregnancy of different age groups(P>0.05).There were no statistically significant differences among different ages,educational levels,and hypertensive in the carrier rate of women with late pregnancy(P>0.05).The carrier rate of women with late pregnancy of different BMI,presence or absence of GDM,VVC,sexual life in late pregnancy,history of abortion,delivery history and vaginal delivery history were compared,the differences were statistically significant(P<0.05).BMI,GDM,VVC,sexual life in late pregnancy,birth history,vaginal birth history and abortion history were all independent risk factors for GBS carrier rate in late pregnancy(P<0.05).Conclusion:Age and hypertension and other factors have little correlation with the carrier rate.The risk factors of group B streptococcus infection in women in the late pregnancy include BMI,GDM,VVC,abortion history,vaginal delivery history,sex life in the late pregnancy,etc.The incidence rate can be reduced by taking corresponding preventive measures.