硫酸镁联合硝苯地平缓释片对重度妊娠期高血压疾病患者围产结局的影响

Effect of Magnesium Sulfate Combined with Nifedipine Sustained Release Tablets on Perinatal Outcomes in Patients with Severe Hypertension Disorders Complicating Pregnancy

目的:探究硫酸镁联合硝苯地平缓释片对重度妊娠期高血压疾病患者围产结局的影响。方法:选取2015年1月-2017年1月本院收治的妊娠期高血压疾病120例作为研究对象,按照随机数字表法将其分为对照组(n=60)和观察组(n=60)。对照组给予硫酸镁治疗,观察组给予硫酸镁联合硝苯地平缓释片治疗,比较两组治疗效果、血流动力学指标、血压以及不良围产结局情况。结果:观察组治疗总有效率为91.67%,明显高于对照组的75.00%(P<0.05)。治疗前两组血液黏稠度、血细胞比容、RI、S/D血流动力学指标相比,差异均无统计学意义(P>0.05);治疗后两组血液黏稠度、血细胞比容、RI、S/D血流动力学指标均较治疗前下降,且观察组较对照组明显(P<0.05)。治疗前两组血压比较,差异无统计学意义(P>0.05);治疗后两组血压均改善,且观察组血压变化明显优于对照组(P<0.05)。观察组围产结局情况明显优于对照组(P<0.05)。结论:硫酸镁联合硝苯地平缓释片治疗妊娠期高血压疾病临床效果显著,可有效降低血压,并可有效减少外周阻力,促进胎盘血流供应,改善围产结局,显著降低不良妊娠结局发生率,具有良好的临床应用效果。

Objective:To investigate the effect of Magnesium Sulfate combined with Nifedipine Sustained Release Tablets on perinatal outcomes in patients with severe hypertension disorders complicating pregnancy.Method:A total of 120 cases of hypertension disorders complicating pregnancy admitted to our hospital from January 2015 to January 2017 were selected as the study subjects.They were divided into the control group(n=60)and the observation group(n=60)according to the random number table method.The control group was treated with Magnesium Sulfate,and the observation group was treated with Magnesium Sulfate combined with Nifedipine Sustained Release Tablets.The effects,hemodynamic parameters,blood pressure and adverse perinatal outcomes of two groups were compared before and after treatment.Result:The total effective rate of treatment of the observation group was 91.67%,which was higher than 75.00%of the control group(P<0.05).There were no significant differences in blood viscosity,hematocrit,RI,S/D hemodynamics between two groups before treatment(P>0.05).After treatment,the blood viscosity,hematocrit,RI and S/D hemodynamic indexes of the two groups decreased compared with those before treatment,and the observation group was significantly lower than those of the control group(P<0.05).There was no significant difference in blood pressure between the two groups before treatment(P>0.05);after treatment,blood pressure in both groups improved,and the change of blood pressure in the observation group was significantly better than that in the control group(P<0.05).The perinatal outcome of the observation group was significantly better than that of the control group(P<0.05).Conclusion:Magnesium Sulfate combined with Nifedipine Sustained Release Tablets in the treatment of hypertension disorders complicating pregnancy has a significant clinical effect,can effectively reduce blood pressure,and the patients’peripheral resistance,promote placental blood supply,improve the perinatal outcome,significantly reduce the incidence of adverse pregnancy outcomes,has a good clinical effect.